Alterations of metabolic and immunological parameters correlate with alterations of the gut microbiota in P2rx7−/− mice. (a,c) Spearman’s ρ (ρs) correlation between the relative abundance of the most represented bacterial genera (with relative abundance >0.5% and detectable in at least 70% of the samples) in the IgA+ (a) and IgA− (c) fractions of faecal microbiota from WT and P2rx7−/− mice with the indicated metabolic and immunological parameters. Solid circles represent the degree of correlation among the variables taken into account. Crossed circles indicate non-significant correlations; significant results with p < 0.05. (b,d) Correlation plots of the significant Spearman’s correlations between bacterial taxa and metabolic and immunological parameters of P2rx7−/− and WT mice in the IgA+ (b) and IgA− (d) fractions of the faecal microbiota. P2rx7−/− and WT mice are represented as yellow diamonds and blue circles, respectively. Dashed lines indicate the regression curves.