Figure 6 | Scientific Reports

Figure 6

From: On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Figure 6

Metabolism of AZ12818677 to AZ12864610. (a,b) Both parent (AZ12818677) (a) and metabolite (AZ12864610) (b) concentrations where quantified in media from the liver compartment following 300 µM parent; measurements were taken at 0, 1, 2, 4, 6 and 24 hours, the solid line is the mean of 3 replicates, with individual data points plotted. (c) Metabolic reaction representing de-acetylation/amide hydrolysis of AZ12818677 (parent) to form AZ12864610 (metabolite). (d) Determination of AZ12864610 (metabolite) concentrations at different time points in cardiomyocytes/media following incubations with AZ12818677 (parent).

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