Figure 3 | Scientific Reports

Figure 3

From: On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Figure 3

Terfenadine induced PK response in the heart only and heart:liver models. Both terfenadine (black) and fexofenadine (red) concentrations where quantified in the media and cellular lysates following 5 µM terfenadine; measurements were taken at 0, 0.5, 1, 4, 12, 16 and 24 hours, the solid line is the mean of 2 replicates with individual data points plotted. (a,b) PK profiles in media from the heart only (a) and heart:liver (b) models. (ce) PK profiles in cellular components from the heart only (c) and heart:liver heart lysates (d); (e) liver lysates MPS models.

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