Figure 2 | Scientific Reports

Figure 2

From: On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Figure 2

Terfenadine induced PD response in the heart only and heart:liver models; (a) representative field potential traces following 5 µM terfenadine (red) or vehicle control (0.1% DMSO) (black) at 4 h in the heart only system. (b) Quantification of FPD and (c) beat rate in the heart only model, 30 second measurements were taken at 0, 0.5, 1, 4, 12, 16 and 24 hours, the solid line is the mean of 3 replicates with individual data points plotted. The red bar represents timepoints where no FPD could be quantified due to the arrhythmogenic effects of terfenadine. (d,e) Quantification of FPD and beat rate in the heart:liver model, 30 second measurements were taken at 0, 0.5, 1, 4, 12, 16 and 24 hours, the solid line is the mean of 3 replicates with individual data points plotted. (f) Cell viability in both the cardiomyocyte and hepatocyte cellular chambers in both the heart only (black) and heart:liver models (heart: green; liver: blue) following 24 hours of terfenadine, individual data points plotted. All data n ≥ 3.

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