Table 1 Biochemical assessment of mitochondrial function in epididymal adipose tissue explants from the vicinity of implanted FGF8b release or placebo pellets.

From: Fibroblast growth factor 8b induces uncoupling protein 1 expression in epididymal white preadipocytes

  Placebo Fgf8b p
1 adipocyte respiration on G3P (nmol O2/s*g tissue) 0.84 ± 0.30 0.86 ± 0.36 0.923
2 cytochrome C oxidase activity (nmol O2/s*g tissue) 3.93 ± 1.64 5.24 ± 2.36 0.289
3 citrate synthase activity (arbitrary unit/g tissue) 1.12 ± 0.51 1.36 ± 0.41 0.396
4 ratio of 1 to 2 0.22 ± 0.04 0.17 ± 0.02 0.016
5 ratio of 1 to 3 0.82 ± 0.31 0.63 ± 0.20 0.244
6 ratio of 2 to 3 3.74 ± 1.42 3.81 ± 1.23 0.935
  1. 1 - Respirometry of isolated, mature adipocytes with glycerol-3-phosphate (G3P) as substrate. 2–Cytochrome C oxidase activity in tissue homogenates. 3 – Citrate synthase activity in tissue homogenates. 4–6 – Ratios between 1–3. None of the parameters assessed was significantly different (Sidak’s multiple comparisons test), n = 6.