Figure 3 | Scientific Reports

Figure 3

From: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

Figure 3

Anti-hCLDN18.2 or anti-hCD3 antibodies binds CHO/hCLDN18.2 or human Pan-T cells dose-dependently. Schematic of the two anti-CLDN18.2 therapeutic molecule formats: a full length fully human IgG2ΔA D265A bispecific or diabody generated by combining CLDN18.2 and CD3 targeting arms though hinge mutations. (a) CHO engineered expressing hCLDN18.2 and human Pan-T cells were assayed for anti-CLDN18.2-CD3 Bispecific and diabody cell binding. The anti-CLDN18.2 arm of the bispecific and diabody binds in a dose-dependent manner to CHO/CLDN18.2 cell line (b) and the anti-CD3 arm to Pan-T cells (c).

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