Figure 4 | Scientific Reports

Figure 4

From: PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection

Figure 4

The lungs of mice infected with PA-X deficient virus contain less immunostimulatory RNA. (A) Schematic of the assay using HEK293-p125 reporter cells. (B) RNA extracted from the lungs of infected mice was transfected into HEK293-p125 cells. 18 hours later, induction of the IFNB promoter was determined. Data are shown as fold induction compared to cells treated with transfection reagent only and are from 20 (mock), 26 (PR8 WT) and 24 (PR8 FS) mice per group ± s.e.m. and are pooled from five independent experiments. *P ≤ 0.05, ns not significant; two-way ANOVA.

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