Figure 5 | Scientific Reports

Figure 5

From: Enhancement of HIFU ablation by sonosensitizer-loading liquid fluorocarbon nanoparticles with pre-targeting in a mouse model

Figure 5

Detection of the combination between the nanoparticles and the cells (600×). Parallel plate flowing chamber test was performed to detect the combination between the nanoparticles and HUVECs. (A) The pre-targeting (HMME+PFP/PLGA-SA) group. (B) The direct targeting (HMME+PFP/PLGA-Ab) group. (C) The HMME+PFP/PLGA-SA group. (D) The HMM+PFP/PLGA group. (E) The antibody blocking group. In the pre-targeting (HMME+PFP/PLGA-SA) group, there were large amounts of nanoparticles binding to the cell surface and accumulating around the cells. In the direct targeting (HMME+PFP/PLGA-Ab) group, relatively few nanoparticles adhering to the cell surface were observed. For the HMME/PLGA, PFP/PLGA, and antibody blocking groups, there were almost no nanoparticles binding to the cell surface.

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