Table 1 Metabolite concentrations in plasma samples and three group comparison.

From: Different Circulating Trace Amine Profiles in De Novo and Treated Parkinson’s Disease Patients

metabolite H (n = 10) DN (n = 21) PD (n = 27) Kruskal-Wallis p-value H vs. DN p-valuea H vs. PD p-valuea DN vs. PD p-valuea
TYRA 0.418 (0.344–0.481) 0.71 (0.547–0.910) 1.02 (0.895–1.546) <0.0001 0.02 <0.0001 0.002
β-PEA 7.380 (3.029–9.222) 2.535 (2.214–4.322) 1.162 (0.613–3.687) 0.001 0.17 0.0009 0.18
OCT 0.077 (0.038–0.119) 0.061 (0.033–0.076) 0.044 (0.028–0.092) 0.57    
TRY 1.467 (0.971–1.991) 2.335 (1.567–3.204) 1.084 (0.868–3.068) 0.11    
SYN 0.016 (0.015–0.164) 0.051 (0.039–0.063) 0.194 (0.081–0.328) 0.015 1.00 0.12 0.19
NE 3.588 (2.521–5.294) 3.466 (1.966–4.555) 2.41 (1.645–2.801) 0.012 1.00 0.03 0.05
5-HT 441.5 (167.5–777.2) 272.6 (28.86–646.5) 49.3 (13.3–252.1) 0.006 0.73 0.009 0.10
E 0.289 (0.227–0.404) 0.279 (0.202–0.392) 0.267 (0.199–0.385) 0.69    
MTN 0.191 (0.151–0.243) 0.255 (0.183–0.334) 0.308 (0.228–0.370) 0.001 0.14 0.0008 0.19
ADE 218.7 (164.6–282.1) 209.8 (133.2–391.7) 187.00 (124.2–402.1) 0.88    
GABA 0.206 (0.181–0.234) 0.227 (0.196–0.259) 0.218 (0.182–0.261) 0.52    
TYRO 59.0 (55.8–67.7) 58.6 (53.4–67.4) 75.5 (64.2–86.5) 0.002 1.00 0.04 0.003
TRP 52.5 (47.3–57.7) 46.4 (41.1–58.7) 55.7 (51.2–63.7) 0.07    
  1. Concentrations are reported as median and interquartile range (25–75%).
  2. aAdjusted p-value obtained by Dunn’s multiple comparisons test.