Table 3 kinetics of echocardiography parameters in mice implanted with Iso pump after Scramble (Scr) or Orai3 siRNA intramyocardial injection.

From: Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling

Iso mice (iso pump implantation at d0)
Time of echocardio-graphy d0 d8 d12 d15 d22 d28
Injection at d8 Scr (n = 11) Orai3 (n = 22) p Scr (n = 11) Orai3 (n = 22) p Scr (n = 11) Orai3 (n = 22) p Scr (n = 11) Orai3 (n = 15) p Scr (n = 8) Orai3 (n = 8) p Scr (n = 8) Orai3 (n = 8) p
HR (bpm) 624 ± 7 634 ± 3 ns 668 ± 11 652 ± 9 ns 606 ± 15 619 ± 9 ns 622 ± 11 632 ± 12 ns 630 ± 6 609 ± 8 ns 594 ± 29 618 ± 11 ns
IVSd (mm) 0.6 ± 0.01 0.7 ± 0.01 ns 1 ± 0.02 1 ± 0.02 ns 1 ± 0.06 0.9 ± 0.03 ns 1 ± 0.04 0.8 ± 0.03 <0.05 0.9 ± 0.04 0.8 ± 0.03 ns 0.8 ± 0.04 0.7 ± 0.04 ns
LVd (mm) 3.6 ± 0.05 3.5 ± 0.04 <0.05 3.4 ± 0.11 3.6 ± 0.07 ns 3.7 ± 0.19 3.9 ± 0.09 ns 3.4 ± 0.17 4.0 ± 0.10 <0.05 3.8 ± 0.18 4.0 ± 0.14 ns 4.1 ± 0.24 3.8 ± 0.14 ns
PWd (mm) 0.7 ± 0.02 0.7 ± 0.01 ns 0.9 ± 0.03 0.9 ± 0.02 ns 0.9 ± 0.05 0.8 ± 0.02 <0.05 0.9 ± 0.05 0.7 ± 0.04 <0.01 0.8 ± 0.02 0.7 ± 0.03 ns 0.7 ± 0.05 0.6 ± 0.03 ns
IVSs (mm) 1.1 ± 0.02 1.1 ± 0.02 ns 1.5 ± 0.03 1.5 ± 0.04 ns 1.4 ± 0.07 1.4 ± 0.04 ns 1.5 ± 0.06 1.1 ± 0.05 <0.05 1.4 ± 0.06 1.3 ± 0.04 ns 1.3 ± 0.06 1.3 ± 0.07 ns
LVs (mm) 2.0 ± 0.04 1.9 ± 0.02 <0.05 1.8 ± 0.08 2.0 ± 0.08 ns 2.1 ± 0.19 2.4 ± 0.12 ns 1.9 ± 0.16 2.6 ± 0.14 <0.01 2.2 ± 0.17 2.6 ± 0.17 ns 2.6 ± 0.29 2.4 ± 0.16 ns
PWs (mm) 1.2 ± 0.03 1.1 ± 0.02 ns 1.3 ± 0.04 1.4 ± 0.02 <0.05 1.3 ± 0.06 1.2 ± 0.03 ns 1.3 ± 0.06 1.0 ± 0.05 <0.01 1.2 ± 0.03 1.0 ± 0.04 <0.01 1.0 ± 0.07 1.0 ± 0.06 ns
h/r 0.3 ±0.007 0.3 ±0.004 ns 0.56 ±0.018 0.5 ±0.017 ns 0.54 ±0.044 0.4 ±0.016 <0.05 0.55 ±0.041 0.40 ±0.021 <0.01 0.44 ±0.024 0.39 ±0.019 ns 0.38 ±0.042 0.36 ±0.019 ns
EF (%) 83.1 ± 0.5 83.5 ± 0.2 ns 84.6 ± 0.8 81.7 ± 1.6 ns 80.0 ± 2.6 75.7 ± 2.1 ns 82.8 ± 2.2 68.5 ± 3.2 <0.05 79.4 ± 1.9 70.6 ± 3 <0.01 72.7 ± 4.8 74.1 ± 2.7 ns
FS (%) 45.9 ± 0.5 46.3 ± 0.2 ns 47.7 ± 0.9 45.1 ± 1.4 ns 44.1 ± 2.6 39.6 ± 1.6 ns 46.5 ± 2.1 34.2 ± 2.2 <0.05 44.6 ± 1.6 35.3 ± 2.4 <0.01 38.3 ± 2.6 38.1 ± 2.4 ns