Figure 9 | Scientific Reports

Figure 9

From: Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling

Figure 9

Orai3 enhances hypertrophy, promotes resistance to oxidative stress in adult hypertrophied cardiomyocytes and during EACH limits evolution towards HF. Mechanistically, a TNFα paracrine signaling potentially mediated by the cardiac inflammatory CD11b/c cells promotes TNFR2-dependent activation of store-independent arachidonic acid-dependent Orai3-related Ca2+ influx enhancing hypertrophy and inducing resistance to H2O2. Knockdown of Orai3 at the onset of adaptive hypertrophy suppresses the EACH response and accelerates transition towards HF.