Figure 7 | Scientific Reports

Figure 7

From: microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Figure 7

Topical administration of miR-155 inhibitor restores FGF7 expression. (A) Representative images of FGF7 protein expression assessed by fluorescence microscopy on mouse wound skin tissue of non-diabetic (n = 4) and diabetic mice treated with Neg. Ctrl. oligo (control, n = 3), 2.5 nmol of miR-155 inhibitor (n = 3) or 2.5 nmol of Seed miR-155 inhibitor (n = 3), collected at day 10 post-wounding. Seed miR-155 inhibitor: LNA-oligonucleotides binding to seed region of miR-155. Blue – DAPI, Green – FGF7. (B) Quantification of FGF7 expression. Data are presented as mean ± SD of the percentage of non-diabetic condition. Data were analyzed using one-way ANOVA with Dunnet’s post hoc correction; **p < 0.01, ***p < 0.001 vs non-diabetic.