Figure 6 | Scientific Reports

Figure 6

From: microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Figure 6

Topical administration of miR-155 inhibitor reduces T-cell and macrophage wound infiltration in diabetic mice. (A) Representative fluorescence microscopy images of T-cells (CD3+) and macrophages (CD68+) in wound skin tissue of diabetic mice treated with 2.5 nmol Neg. Ctrl. oligo (control) or 2.5 nmol of miR-155 inhibitor, collected at day 10 post-wounding (n = 3 for each group with one representative example per group shown). (B) Quantifications of the number of CD68+ macrophages and (C) Quantifications of the number of CD3+ T-cells. Blue – DAPI, Green – CD3 or CD68. The results were analyzed using student’s t-test. ***p < 0.001 vs Neg. Ctrl. oligo.