Table 1 Demographics of the study subjects in the discovery and verification stages.

From: Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis

Characteristics CON Target Screening Stage Clinical Validation Stage
SIRS Sepsis Severe sepsis Death P value CON sepsis septic shock P value
N = 20 N = 20 N = 20 N = 20 N = 20 N = 10 N = 12 N = 19
Age (years) 61.5 ± 14.2 57.7 ± 16.8 63.8 ± 17.7 69.6 ± 14.2 59.0 ± 17.4 0.158 64.7 ± 16.1 58.1 ± 12.2 68.9 ± 12.5 0.104
Gender (n, %)       0.456     0.201
  Male 11 (55) 12 (60) 11 (55) 15 (75) 15 (75)   6 (60) 11 (91.7) 15 (8.9)  
  Female 9 (45) 8 (40) 9 (45) 5 (25) 5 (25)   4 (40) 1 (8.3) 4 (21.1)  
WBC counts (×109/L) 7.9 ± 2.9 16.4 ± 4.2 10.9 ± 3.9 13.4 ± 7.9 13.3 ± 7.6 <0.001 6.6 ± 1.2 11.9 ± 7.9 15.7 ± 7.5 0.005
APACHE II score 8 ± 3 13.2 ± 6.5 19.5 ± 6.5 23.4 ± 5.4 <0.001 10 ± 4 17.9 ± 6.7 25.4 ± 6.1 <0.001
SOFA score 3.9 ± 2.5 8.6 ± 4.1 12.2 ± 3.4 <0.001 9.5 ± 3.5 13.0 ± 3.7 0.015
Pathogens detected (n, %)
  Gram-positive bacteria 6 (30) 7 (35) 8 (40) 0.803 7 (58.3) 10 (52.6) 0.756
  Gram-negative bacteria 16 (80) 13 (65) 16 (80) 0.449 10 (83.3) 16 (86.2) 0.948
  Fungi 5 (25) 8 (40) 8 (40) 0.517 5 (41.7) 7 (36.8) 0.788
Etiological factors (n, %)
  Pulmonary infection 14 (70) 14 (70) 16 (80) 0.711 11 (91.7) 15 (78.9) 0.348
  Abdominal infection 4 (20) 5 (25) 2 (10) 0.459 4 (33.3) 6 (31.6) 0.919
  Bacteremia 5 (25) 3 (15) 5 (25) 0.675 2 (16.7) 2 (10.5) 0.619
  Urinary infection 4 (20) 6 (30) 4 (20) 0.689 4 (33.3) 6 (31.6) 0.919
  Trauma/soft tissue infection 4 (20) 7 (35) 7 (35) 0.49 4 (33.3) 11 (57.9) 0.183
  Others 0 (0) 2 (10) 1 (5) 0.349 0 (0) 2 (10.5) 0.245
  1. *A patient might have more than one pathogenic bacterial infection. Therefore, the sum of the frequencies (pathogens detected and etiological factors) was higher than effective, and the sum of the percentages could be greater than 100%.