Figure 7 | Scientific Reports

Figure 7

From: eBrain: a Three Dimensional Simulation Tool to Study Drug Delivery in the Brain

Figure 7

Internal functions of the simulation parameters extracted from multiple simulation runs. (A) Stimulation capacity (Green line) as calculated in a plot of neuron activity over time. (B) Capacity as function of dose and tissue uptake. (C) Schematic representation of capacity function regimes and activity domains. (D) Stimulation lag (Red star) as calculated in a plot of neuron activity over time. (E) Stimulation lag as function of tissue uptake and dose. (F) Schematic representation of stimulation lag function regimes and activity domains. (G) Stimulation rate (Blue line) as calculated in a plot of neuron activity over time. (H) Stimulation rate as function of tissue uptake and dose. (I) Schematic representation of stimulation rate function regimes and activity domain. The curve in left column is of a representative simulation run under dose ~2e3 and uptake ~1e−3. Maps in the middle column are calculated for 100 runs with different tissue uptake and dose (dose 100e−3:0.001e−3; uptake 100e−3:0.001e−3. Note the logarithmic scales). Schematic representation at the right column designate monotonic (Cyan) and skewed distribution (Orange) functions and the activity domains: I - activation area, II - no activity due to insufficient tissue uptake, III - no activity due to absorption at tissues prior to the substantia nigra). Notice the interdependency diagonal thresholds (Black).

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