Stimulation of cell population at the Pars Compacta region of the substantia nigra (presented in three different modes, MRI (Top), diffusion (Middle) and tissue uptake (Bottom)). Four sampling points at time 0.33, 0.5, 0.66 and 0.833 simulated hours under tissue uptake of 40e−3 simulated absorption capacity units and dose of 100e3 simulate Molar. Cell in the native form are colored green, stimulated cells change their color to yellow, and to red when they are fully stimulated. See also Supplementary Clip 4. (B) Average of a repetitive 10 independent runs of the simulation with dose ~2e3 and uptake ~1e−3. Cyan indicates the error bar over the runs. (C) Multiple runs under various initial dose (1000e3:0.1e3 simulated Molar) and tissue uptake (100e−3:0.001e−3 simulated absorption capacity) conditions. Each curve represents a single run of the simulation.