Table 5 Interaction between maternal folic acid supplement and infant genotypes of MTR gene on the risk of CHDs.

From: Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese population

Marker Genotype Maternal folate intake Case Control aORa (95%CI) P 1 b P 2 c
rs1770449 TT no 40 60 Ref. 0.015 0.014
TT yes 42 81 1.123 (0.619, 2.039)   
CT or CC no 51 26 3.262 (1.656, 6.429)   
CT or CC yes 27 41 1.158 (0.585, 2.295)   
rs1050993 GG no 40 60 Ref. 0.019 0.016
GG yes 42 82 1.109 (0.611, 2.012)   
AG or AA no 51 26 3.263 (1.656, 6.429)   
AG or AA yes 27 40 1.185 (0.597, 2.354)   
  1. aOdds ratios adjusted for maternal age, maternal education level, fetal gender.
  2. bP1: counted by logistic regression. cP2: counted by cross analysis.