Table 2 Key genes underlying dichotomous neurobiological responses in Clock∆19/∆19 mice.

From: The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock∆19/∆19 Mice With Implications for Circadian Medicine

Gene Gene Name
Bmal1 Brain And Muscle ARNT-Like 1
Per2 Period 2
Cry2 Cryptochrome 2
Dbp D Site Of Albumin Promoter (Albumin D-Box) Binding Protein
Tef Thyrotrophic Embryonic Factor
Gabra2 Gamma-Aminobutyric Acid Type A Receptor Alpha2 Subunit
Fabp7 Fatty Acid Binding Protein 7
Adcy5 Adenylate Cyclase 5
Ppp1r1b Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B
Gng7 G Protein Subunit Gamma 7
Drd2 Dopamine Receptor D2
Npy Neuropeptide Y
Pde1b Phosphodiesterase 1B
Hdac1 Histone Deacetylase 1
Adora2a Adenosine A2a Receptor
Grm2 Glutamate Metabotropic Receptor 2
Slc38a3 Solute Carrier Family 38 Member 3
Camk2n2 Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2
Phactr2 Phosphatase And Actin Regulator 2
Mid1 Midline 1
Ndn Necdin
Neurl1b Neuralized E3 Ubiquitin Protein Ligase 1B
Nlgn3 Neuroligin 3
Mag Myelin Associated Glycoprotein
Mfn2 Mitofusin 2
Grm3 Glutamate Metabotropic Receptor 3
Ndn Necdin
Irak1 Interleukin 1 Receptor Associated Kinase 1
Rapgef4 Rap Guanine Nucleotide Exchange Factor 4
Cspg5 Chondroitin Sulfate Proteoglycan 5
  1. Genes listed are as profiled in Fig. 6, and were identified as significantly different in the mPFC, or hippocampus, or both. Further details about these genes are provided in Supplementary Table S1, including Affymetrix identifiers, fold change values, gene expression values under all conditions tested (baseline, MI, HF) in Clock∆19/∆19 and WT mice, chromosome location, and tags to esemble, entrezgene, genebank and GO databases. Additional genes identified but not mapped in Fig. 6 are also provided in Supplementary Table S1.