Figure 4 | Scientific Reports

Figure 4

From: The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock∆19/∆19 Mice With Implications for Circadian Medicine

Figure 4

Visual-spatial memory differs in Clock∆19/∆19 and WT mice. (a) At baseline, Clock∆19/∆19 mice show impaired short term OiP memory (5 minutes) compared to WTs (n = 23 Clock∆19/∆19, n = 27 WT). (b) At 1 week post-myocardial infarction, OiP performance is impaired in both Clock∆19/∆19 mice and WT mice at both immediate (45 seconds) and 5-minute retention delays (n = 16 Clock∆19/∆19, n = 17 WT). (c) In the 8-week HF mice, OiP performance is impaired in Clock∆19/∆19 vs. WT mice at immediate (45 second) delays, and is for both Clock∆19/∆19 and WT mice at 5-minute retention delays (n = 16 Clock∆19/∆19, n = 17 WT). Object oddity discrimination is similar at (d) baseline (n = 5/group), (e) 1 week post-myocardial infarction (n = 6/group), and in the (f) 8 week HF mice (n = 16 WT, n = 17 Clock∆19/∆19), as the oddity preference significantly differed from 0.33 (chance performance). However, Clock∆19/∆19 mice performed worse than WT at 1 week post-myocardial infarction *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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