Table 2 Significant changes of 5-Ht2cr mRNA editing isoforms between PWScrp/m5LoxP and wild type mice choroid plexus samples.

From: Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice

Pattern Mean RPKM WT Mean RPKM LoxP Fold change WT/LoxP P-value SIG pBH WT % LoxP %
CD 126959 104482 1.2 0.0009 *** 0.02 12.6 11.8
AD 44104.5 33894 1.3 0.0013 ** 0.0185 4.4 3.8
ABD 32223 18402 1.75 6.52E-05 **** 0.0072 3.2 2.1
ED 23259 19153 1.2 0.03068 * 0.179 2.3 2.17
ACD 19010 14490 1.3 0.0043 ** 0.053 1.9 1.6
ABCD 12761 5132 2.5 0.00027 *** 0.0099 1.3 0.58
E 11309 17713 0.64 0.0062 ** 0.0627 1.1 2
AC 5546 3450 1.6 0.00095 *** 0.0175 0.55 0.3
AECD 3544 1277 2.8 0.0098 ** 0.09 0.35 0.14
BCD 2631 535 4.9 0.024 * 0.156 0.26 0.06
CDH 262 79 3.3 0.019 * 0.1288 0.026 0.009
1AD 64.5 44 1.46 0.037 * 0.1973 0.006 0.005
ADG 61.5 46 1.34 0.044 * 0.2218 0.006 0.0052
ABDG 44 25 1.8 0.029 * 0.1792 0.004 0.0028
1ABD 35.5 22 1.6 0.012 * 0.0867 0.0035 0.0025
ABCDG 24.6 8 3.2 0.0013 ** 0.0185 0.002 0.00087
ABCDF 21 6.5 3.2 0.00016 *** 0.009 0.002 0.0007
3ABCD 19.5 7 2.9 0.005 ** 0.0554 0.0019 0.00076
1ABCD 19 4 5 0.0003 *** 0.0087 0.00185 0.0004
ABCDH 12 3 3.6 0.0112 * 0.0867 0.0012 0.0004
3AC 11 5 2.33 0.01 * 0.0867 0.001 0.00056
  1. Pattern: Combinations of edited sites contribute to a variety 5-Ht2cr mRNA editing patterns. They are labeled according the designations of the contributing editing sites (Fig. 1A). Mean RPKM WT and LoxP: Calculated mean of RPKM values for wild type (WT) and, PWScrp/m5LoxP (LoxP) samples. Fold change WT/LoxP: Fold change between wild type (WT) and PWScrp/m5LoxP (LoxP) editing patterns. P-value: P-value of Student’s t-test. SIG: Graphpad formatting - asterisks describe p-values levels of statistical significance. pBH: “False Discovery Rate” correction for multiple comparisons. WT(%) and LoxP(%): The percentage of detected receptor isoforms in wild type (WT) and PWScrp/m5LoxP (LoxP) mouse choroid plexuses, is indicated.