M:L ratios and total pathology scores determined in RM (blue), MCM (red) and CCM (green) following aerosol exposure to M. tuberculosis at a presented dose in the range 250–1400 CFU. (a) M:L ratio of progressors and controllers for infected RM, MCM and CCM group medians with interquartile range at determined at intervals after MTB aerosol exposure. RM progressors at week 4 were significantly different from week 0 (dotted blue horizontal line) (*p = 0.02), MCM progressors were significantly lower than week 0 (dotted horizontal red line) (*p = 0.02) and MCM controllers were significantly lower than week 0 at week 12 (red horizontal line) (*p = 0.02) as measured using Mann Whitney U-test (*p=<0.05). RM n = 9, MCM n = 6, CCM n = 7. (b) Total pathology scores of progressors (triangles) and controllers (circles) of infected RM, MCM and CCM. MCM controllers had significantly higher total pathology scores than both RM controllers (*p = 0.04) and CCM controllers (*p = 0.03) as measured using Mann Whitney U-test. (*p=<0.05). RM controllers n = 5, RM progressors n = 4, MCM controllers n = 3, MCM progressors n = 3, CCM controllers n = 7. (c) Spearman’s rank correlation of the final M:L value for each animal (i.e. week 12 or when they reached humane end point criteria) versus the pathology scores r = 0.51, p = 0.016. Controllers = circles, progressors = triangles, RM = blue, MCM = red, CCM = green. *p=<0.05. RM controllers n = 5, RM progressors n = 4, MCM controllers n = 3, MCM progressors n = 3, CCM controllers n = 7.