Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
All parameters associated with ALSFRS-r progression from the adjusted models shown in Table 1 (interaction with time < 0.10) were included in a multivariable linear mixed model. Neurological parameters were removed manually using the same backward selection approach. The multivariate analysis was performed on the population for specific parameters using the final mixed model. aa coefficient corresponding to the effects of a 10 point increase. Analysis was adjusted for treatment and pre-specified baseline factors with their interactions to time (BMI, MMT, SVC, sodium and time since the onset of signs).
Examples of prediction of the monthly rate of reduction of ALSFRS-r: