Figure 4 | Scientific Reports

Figure 4

From: The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer

Figure 4

The effects of the death rate (no death, low, and high) and tradeoff boundaries (open, convex and concave) on the evolution of migration and proliferation rates. The probability of death for a single cell is once per week (high death rate) and once every two weeks (low death rate). (A) The spatial layout and (B) the frequency of trait combinations is shown for a single representative simulation for each case, where the red points and line mark the average trait values every 5 days for the first month. The black points show the continued evolutionary trajectory up until 3 months. The background colors correspond to the density of cell traits at 3 months; Brightly colored areas correspond to high densities, and the completely white area contains no cells. The asterisk shows the average trait values at 12 months. Replicate simulation runs are shown in Fig. S1.

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