Figure 2 | Scientific Reports

Figure 2

From: The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer

Figure 2

Mathematical model details. (A) A single cell with the smallest proliferation and migration rates centered in a 4-mm radial boundary initializes the simulation. The cell diameter is 20 μm, and its area of interaction is defined by a 200 × 200 micron neighborhood (more detail can be found in the Methods section). (B) Imposing tradeoffs by bounding the phenotype space. When the whole space is open (thin solid line), all phenotypes are allowed. The convex (thick solid line) and concave (dashed line) bound the space as shown. The set of evolutionarily feasible traits lies within (fitness set) and on the tradeoff line (active edge). The trait value of a daughter cell can mutate up to one unit in any direction as long as it stays within the bounded region.

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