Figure 3 | Scientific Reports

Figure 3

From: Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes

Figure 3

PrP octa-repeat mRNA adopts A-helical RNA structure. (a) CD spectra of wt and ΔG4 PrP octa-repeat mRNA under control (LiCl) and G-quadruplex-favouring conditions (KCl +/− PDS) at temperatures ranging from 25 to 95 °C show characteristic signature of A-helical dsRNA. (b) Melting curves were extracted from the maximal ellipticity of the prominent 264 nm peak and normalized to the molar ellipticity at 25 °C. Points were fitted to a 4 parameter sigmoidal curve.

Back to article page