Table 2 HRsa per 39 mg/dL (1 mmol/L) TC increase according to sex, age, and TC range.

From: Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults

TC range, Age group, Men Women p value for interaction between sexes
mg/dL (mmol/L) years No. of deaths p-value HR (95% CI) No. of deaths p-value HR (95% CI)
50–449 All ages 453,959 <0.001 0.90 (0.89–0.90) 239,545 <0.001 0.95 (0.95–0.96) <0.001
  18–34 16,111 0.098 0.98 (0.97–1.00) 4,580 0.231 1.02 (0.99–1.06) 0.071
  35–44 37,382 <0.001 0.90 (0.89–0.91) 10,540 0.468 0.99 (0.97–1.01) <0.001
  45–54 67,370 <0.001 0.85 (0.84–0.85) 21,552 <0.001 0.95 (0.93–0.96) <0.001
  55–64 116,119 <0.001 0.86 (0.86–0.87) 45,787 <0.001 0.92 (0.92–0.93) <0.001
  65–74 144,609 <0.001 0.92 (0.91–0.92) 88,046 <0.001 0.96 (0.95–0.96) <0.001
  75–99 72,368 <0.001 0.94 (0.93–0.95) 69,040 <0.001 0.97 (0.96–0.97) <0.001
50–199 All ages 283,239 <0.001 0.75 (0.74–0.75) 114,022 <0.001 0.81 (0.80–0.82) <0.001
  18–34 10,889 <0.001 0.87 (0.84–0.90) 3,608 0.009 0.92 (0.87–0.98) 0.079
  35–44 21,936 <0.001 0.70 (0.68–0.72) 7,072 <0.001 0.86 (0.83–0.90) <0.001
  45–54 38,832 <0.001 0.64 (0.63–0.65) 10,839 <0.001 0.77 (0.74–0.80) <0.001
  55–64 70,570 <0.001 0.68 (0.67–0.69) 20,274 <0.001 0.72 (0.70–0.74) <0.001
  65–74 91,938 <0.001 0.80 (0.79–0.81) 39,339 <0.001 0.80 (0.78–0.81) 0.889
  75–99 49,074 <0.001 0.86 (0.85–0.88) 32,890 <0.001 0.87 (0.86–0.89) 0.356
200–449 All ages 170,720 <0.001 1.07 (1.07–1.08) 125,523 <0.001 1.06 (1.05–1.06) <0.001
  18–34 5,222 <0.001 1.15 (1.10–1.19) 972 0.006 1.14 (1.04–1.26) 0.953
  35–44 15,446 <0.001 1.12 (1.09–1.14) 3,468 <0.001 1.19 (1.14–1.25) 0.017
  45–54 28,538 <0.001 1.08 (1.06–1.09) 10,713 <0.001 1.08 (1.05–1.11) 0.790
  55–64 45,549 <0.001 1.07 (1.05–1.08) 25,513 <0.001 1.06 (1.05–1.08) 0.761
  65–74 52,671 <0.001 1.07 (1.05–1.08) 48,707 <0.001 1.05 (1.04–1.07) 0.143
  75–99 23,294 0.008 1.03 (1.01–1.05) 36,150 <0.001 1.03 (1.02–1.05) 0.535
  1. CI, confidence interval; HR, hazard ratio; TC, total cholesterol.
  2. aHRs were calculated by Cox models stratified by age (baseline age, years: 18–24, 25–34, 35–44, 45–54, 55–64, 65–74, 75–84, 85–99), after adjustement for age at baseline, sex (if applicable), smoking status, alcohol use, physical activity, known history of heart disease, stroke, or cancer, body mass index, systolic blood pressure, and total cholesterol.
  3. To convert glucose from mg/dL to mmol/L, multiply by 0.02586.