Figure 2 | Scientific Reports

Figure 2

From: Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression

Figure 2

CycT suppresses the growth of subcutaneous NSCLC tumor xenografts. (A) Representative bioluminescence images of mice bearing subcutaneous H1299 tumor xenografts treated with CycT (7.5 mg/kg every 3 days, I.V.) or saline (control). n = 6/group. (B) Average tumor mass after 4.5 weeks of CycT treatment. Data are plotted as mean ± standard deviation. For statistical analysis, the levels in CycT treated tumors were compared to the levels in control tumors with a Welch 2-sample t-test. **p-value < 0.005. (C) Representative H&E images of tumors with CycT or without CycT (control) treatment.

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