Table 2 The concentrations of glycolysis metabolites in erythrocytes, measured in various studies, as well as the steady-state concentrations of these metabolites obtained in the model (for normal physiological conditions)a.

From: Erythrocytes as bioreactors to decrease excess ammonium concentration in blood

Metabolite Range of the intracellular concentration measured experimentally, mmol/lRBCs Steady-state intracellular concentration calculated in model, mmol/lRBCs References
G6P 0.02–0.11 0.073 53, 54, 58,59,60,61,62,63,– 64
F6P 0.006–0.016 0.024 53, 54, 59,60,61,62,– 63
FDP 0.002–0.03 0.0075 53, 54, 58,59,60,61,– 62, 64
DAP 0.0076–0.035 0.032 53, 54, 61, 62, 65
GAP 0.0048–0.02 0.014 59, 61, 63, 65
1,3-DPG (0.62–4.3) × 10−4 7.2 × 10−4 61, 66
2,3-DPG 4.17–5.7 4.57 53, 54, 59,60,– 61, 63,64,– 65
3-PG 0.055–0.069 0.045 53, 54, 59,60,– 61, 63
2-PG 0.0055–0.012 0.011 53, 54, 59,60,– 61, 63
PEP 0.012–0.018 0.0098 53, 54, 59,60,– 61, 63
NAD 0.032–0.092 0.048 48, 67
NADH 0.001–0.054 0.002 48, 67
4 0.5–0.9 1 53, 68, 69
ATP 1.07–1.8 1.47 60,61,– 62, 64
ADP 0.085–0.3 0.23 60,61,– 62, 64
AMP 0.01–0.05 0.04 60,61,– 62, 64
NADP 0.0003–0.023 0.0003 48, 70,71,– 72
NADPH 0.035–0.06 0.0498 48, 70,71,– 72
Na+ ions 9.2–12.6 10 73, 74
  1. aFor abbreviations, see legend to Fig. 1.