Figure 5 | Scientific Reports

Figure 5

From: Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers

Figure 5

Proposed molecular mechanism of TTR aggregation on the basis of our biochemical analyses and previous experimental results. Under amyloidogenic conditions, tetrameric native TTR is dissociated to monomers, which undergo local conformational changes in AB loop region (pink arrow)31. The amyloidogenic monomers form a dimer through H-H′ interactions. The dimers are then associated to form spherical hexamers, which self-assemble into linear (WT TTR) or annular oligomers (G53A). The structural models for the native tetramer, monomers, and dimers were drawn using MOLMOL60 with pdb code (1F41)61.