Figure 7 | Scientific Reports

Figure 7

From: Patho- physiological role of BDNF in fibrin clotting

Figure 7

rh-BDNF reduces fibrin clot profile of CHD patients in vitro. Recombinant BDNF (rh-BDNF; 5, 25, 135 and 270 pg/ml) or BSA (1 mg/ml: control) was added to plasma from CHD patients before induction of coagulation with thrombin, and fibrin fibers were (a) visualized with Alexa Fluor 488–labeled (20X magnification) and (b) quantified using Image J software. All samples were performed in triplicate and representative images are shown. Data are expressed as mean ± SEM; horizontal bars indicate variation of BDNF levels measured in plasma pools analyzed. n = 12 plasma sample from CHD patients with BDNF < 100 pg/ml. *p < 0.05, **p < 0.01 and ***p < 0.005.

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