Table 1 Administered doses to animals in the different groups.

From: A 14-day repeat dose oral gavage range-finding study of a first-in-class CDI investigational antibiotic, in rats

Group No. Animals/Group (M/F) Target Dose Level (mg/kg/day) Dose Concentrationa (mg/mL)
Main Test
1 3/3 Vehicle Controlb 0
2 3/3 50 5
3 3/3 500 50
4 3/3 1500 150
Toxicokinetic Satellite
5 3/3 Vehicle Controlb 0
6 3/3 50 5
7 3/3 500 50
8 3/3 1500 150
  1. aAppropriate concentrations of Ramizol in vehicle to achieve the target dose level. bSodium phosphate buffer (0.1 M, pH 7.4). Dose volume is 10 mL/kg/day.