Hydrophobic surface potential of a 150 residue vasoinhibin (Vi). (a) Hydrophilic (blue) and hydrophobic (red) residues of PRL and Vi shown in a surface representation model. Changes in the exposure of hydrophobic residues in Vi relative to PRL are indicated (red arrowheads). The localization of secondary structures (H1, L1, and H4) is indicated with white dashed lines. (b) Lateral view of the whole molecule (left) or the L1 region (right) using the surface. (c) Protein surface topography representation of molecular hydrophobic potential of PRL and Vi. Some exposed amino acids are indicated (green dots) and connected sequentially (black dotted line). Colour surface patches represent secondary-structure regions of PRL and Vi. Secondary structures within L1 (H1Vi, H1’ and H1”) are indicated (boxes). A highly hydrophobic patch in Vi is indicated (black arrowhead).