Table 1 Summary of cellular properties of fast- and slow-decay type stretch-sensitive DRG neurons. Cell numbers counted are shown in parentheses.

From: TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons

Genotype Stretch decay type Percentage (Numbers of cells) Stretch-threshold (% of extension) Inhibition by RR % of probenesid-sensitive cells (Numbers of cells) Cell diameter, μm
TRPV2 flox/flox fast 11.3% (68/603)###*** 30%, IQR 10%*** + 93.3% (28/30)* 32.4 ± 0.6***
slow 9.1% (55/603) 10%, IQR 5% 3.4% (1/29) 36.4 ± 0.6
TRPV2flox/flox; Cre fast 0.9% (5/585) 30%, IQR 12.5% NE 25.0% (1/4) 33.0 ± 0.2
slow 6.1% (36/585) 15%, IQR 15% NE 0% (0/29) 36.8 ± 0.8
  1. Stretch threshold is shown as median and IQR (interquartile range) of the percentage of extension from the unloaded length of the stretch chamber. Inhibition by ruthenium red (RR) refers to the sensitivity of the inhibitory effect of RR on stretch-evoked Ca2+ response. NE, not examined. Cell diameter is shown as mean ± S.E.M. For statistical analysis between fast-decay vs. slow-decay neurons in TRPV2flox/flox mice (control), Mann-Whitney U-test was used for stretch-thresholds, and Student’s t-test for the other parameters (***P < 0.001 and *P < 0.05). For comparison between genotypes, Student’s t-test was used (###P < 0.001).