Figure 4 | Scientific Reports

Figure 4

From: TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons

Figure 4

Involvement of TRPV2 in the fast-decay stretch response of DRG neurons. (a) Histogram of the cell diameter of cultured DRG neurons (TRPV2flox/flox, n = 882; TRPV2flox/flox; Cre, n = 895, from three mice per each). (b) TRPV2 immunostaining (green) of the cultured DRG neurons. (c) Percentage of TRPV2-positive DRG neurons from TRPV2flox/flox and TRPV2flox/flox; Cre mice. (d) Representative images of Fura2 Ca2+ imaging. Arrowheads: responsive cells. (e) Percentage of cells sensitive to capsaicin (upper) and probenecid (lower) (TRPV2flox/flox, n = 316; TRPV2flox/flox; Cre, n = 239, from six mice per each). (f) Proportion of fast- and slow-decay neurons (***P < 0.001, χ2-test).

Back to article page