Mechanical and thermal nociception in TRPV2-deficient mice by behavioural pain assays. (a) Radiant heat test. (b) Hot-plate test. (c) Tail-pressure test. (d,e) vFH test to the planter surface of hind paw; dose-response curves (d) and 50% threshold (e). Dots in (e) indicate each animal. Data are mean ± S.E.M. (a–e) or median and IQR (e). *P < 0.05, **P < 0.01 for TRPV2flox/flox; Cre versus TRPV2flox/flox (n = 14 per genotype; t-test for (c) repeated measures two-way ANOVA with Bonferroni’s test for (d) and Mann-Whitney U-test for (e).