Table 1 The effects of acute alcohol administration on amygdala reactivity in human imaging studies.

From: Acute alcohol administration dampens central extended amygdala reactivity

Study N (% Male) EPI Voxel Size (mm3) Normalizationa Design Task Amygdala Results
Present study 49 (53%) 8.0 FSL (BBR) and ANTS (diffeomorphic) Single-blind, placebo-controlled, randomized groups Fearful/Neutral Faces vs. Places (blocked) See the main report
Gilman 2008 12 (42%) 70.3 “AFNI” (affine?) Double-blind, placebo-controlled, randomized cross-over Fearful vs. Neutral Faces (event-related) Voxelwise a. Expression × Treatment, NS b. Expression during Placebo: Fearful > Neutral, p < 0.05, corrected c. Expression during Alcohol: Fearful vs. Neutral, NS ROI a. Expression × Treatment, p = 0.08 b. Expression during Placebo: Fearful > Neutral, p < 0.05 c. Expression during Alcohol: Fearful vs. Neutral, NS
Gilman 2012b 14 (100%) 70.3 “AFNI” (affine?) Double-blind, placebo-controlled, randomized cross-over Fearful vs. Neutral Faces (event-related) Voxelwise a. Expression × Treatment, NR b. Expression during Placebo: Fearful > Neutral, p < 0.01, corrected c. Expression during Alcohol: Fearful vs. Neutral, NS ROI a. Expression × Treatment, p = 0.02 b. Treatment for Neutral: NR c. Treatment for Fearful: Alcohol < Placebo, p = 0.02
Padula 2011c 12 (58%) 58.8 “AFNI” (affine?) Single-blind, placebo-controlled, randomized cross-over Angry/Fearful/Happy Faces vs. Shapes (blocked) Voxelwise a. Stimulus × Treatment, NS b. Stimulus during Placebo: Faces > Shapes, p < 0.05, corrected c. Stimulus during Alcohol: Faces vs. Shapes, NS
Sripada 2011 12 (83%) 70.3 SPM12 (EPI template) Double-blind, placebo-controlled, randomized cross-over Fearful/Angry vs. Happy Faces (blocked) Voxelwise a. Expression × Treatment, NS b. Expression during Placebo: Fearful/Angry > Happy, p < 0.005, uncorrected c. Expression during Alcohol: Fearful/Angry vs. Happy, NS d. Treatment during Fearful/Angry: Alcohol < Placebo, p < 0.005, uncorrected d. Treatment during Happy: NR ROI a. Expression × Treatment, NR b. Expression during Placebo: Fearful/Angry > Happy, p < 0.05 c. Expression during Alcohol: Alcohol < Placebo, NS