The impact of acute alcohol administration on reactivity to emotional faces in the central extended amygdala. (a) Consistent with prior work, voxelwise regression analyses revealed significant activation to emotional faces in the dorsal amygdala (p < 0.05, FWE corrected for the volume of the anatomically defined EAc region-of-interest; total volume: 1,205 voxels; 9,640 mm3). Inset indicates the location of the coronal slice. Significant clusters within the EAc ROI (Supplementary Figure S2) are depicted here. For additional results, see Supplementary Figures S4 and S5 and Supplementary Tables S1 and S2. (b) Voxelwise analyses revealed a significant reduction in reactivity to emotional faces in the region of the left BST in the alcohol compared to the placebo group (same threshold; equivalent to testing the Stimulus × Treatment interaction). The left half of the panel depicts the BST cluster. The right half depicts the BST (green) in the corresponding section of the human brain atlas71. Note the similar appearance of several key landmarks, including the fornix and lateral ventricle (white), as well as the optic tract and anterior commissure (gold). Upper left inset indicates the location of the coronal slice. Upper right inset depicts the myeloarchitecture (Weigert fiber stain) of this region in the atlas. The left BST was the only significant cluster in EAc-focused or whole-brain analyses. For additional results, see Supplementary Figure S6 and Supplementary Table S3. (c) For illustrative purposes, barplot depicts mean standardized regression coefficients extracted from the peak voxel in the BST cluster for the alcohol (light green) and placebo (dark green) groups. Hypothesis testing was performed on a voxelwise basis (corrected for multiple comparisons). Error bars indicate the standard error of the mean. Portions of this figure were adapted with permission from ref.71. Abbreviations—ac, anterior commissure; BST, bed nucleus of the stria terminalis; Cd, caudate; EAc, central division of the extended amygdala; FWE, family-wise error; fx, fornix; GPe, external globus pallidus; GPi, internal globus pallidus; L, left hemisphere; LV, lateral ventricle; OT, optic tract; Pu, putamen; R, right hemisphere; SVC, small volume correction.