Table 3 Antibiotic dose-response and evolution rates.

From: Access to high-impact mutations constrains the evolution of antibiotic resistance in soft agar

Antibiotic N value Median Time to Completiona
15 × MIC 25 × MIC
Ciprofloxacin 3.2 2 2
Doxycycline 1.3 3 5
Polymyxin B 32.2 3 6
Trimethoprim 3.3 2 2
  1. aMedian of three biological replicates. All values in days. N values for E. coli MG1655 were calculated after speed selection. Large N values correspond to steep dose response curves.