Figure 5 | Scientific Reports

Figure 5

From: Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer

Figure 5

KU downregulates epithelial-mesenchymal transition markers and the expression of genes involved in cell motility. (A) Gene expression of EMT markers in Caco2 cells treated with UA and KU. (B) Protein levels of EMT markers in Caco2 cells treated with UA and KU. (C–E) Immunohistochemical analysis of Twist (C), Snail (D), and Slug (E) in isolated liver tissues from the mouse liver metastasis model administered with 20 mg/kg KU. Scale bar, 50 μm. (F) The levels of apoptosis and EMT markers in isolated liver tissues from the mouse liver metastasis model administered with 20 mg/kg KU (n = 2 each group). (G) mRNA expression levels of cell motility-related genes in Caco2 cells treated with UA and KU. Results are reported as the mean ± standard error of the mean. *P < 0.05, **P < 0.01, ***P < 0.001.

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