Table 2 Histopathologic findings in 16 NHPs positive for Zika virus.

From: Evidence of natural Zika virus infection in neotropical non-human primates in Brazil

Sample ID Cerebrum Heart Lung Liver Spleen Kidney
PR 17/03 Autolysis Autolysis Autolysis Autolysis Autolysis Autolysis
PR 17/04 Autolysis Autolysis Mild multifocal suppurative bronchopneumonia; Intravascular microfilariae Moderate multifocal chronic proliferative cholangitis with intralesional trematode ova and adults; Mild to moderate diffuse vacuolar (hydropic) hepatopathy; Intravascular microfilariae Autolysis Minimal focal lymphoplasmacytic interstitial nephritis
PR 17/05 Congestion and multifocal acute hemorrhage. Congestion and multifocal acute hemorrhage. Multifocal acute alveolar hemorrhage Multifocal random mononuclear inflammatory infiltrates and minimal pericholangitis; Mild diffuse vacuolar (hydropic) hepatopathy Mild to moderate, diffuse sinus histiocytosis Minimal multifocal acute tubular degeneration with mild proteinosis; Minimal focal chronic lymphocytic interstitial nephritis
PR 17/07 NSLO NSLO Moderate to severe acute alveolar hemorrhage Marked, diffuse vacuolar (hydropic) hepatopathy Extramedullary hematopoiesis; Lymphoid reactive hyperplasia Without NSLO
PR 17/08 NE Minimal multifocal chronic lymphocytic myocarditis Marked multifocal acute alveolar and bronchial hemorrhage with edema and histiocytosis; Mild multifocal chronic lymphocytic and eosinophilic perivasculitis and mild lymphoid hyperplasia; Focal parabronchial arterial bone marrow embolus. Congestion; Minimal, focal, chronic eosinophilic pericholangitis and minimal reactive changes. Diffuse lymphoid reactive hyperplasia and sinus histiocytosis Mild, multifocal tubular proteinosis; Congestion.
PR 17/11 Multifocal acute cortical neuron necrosis Congestion, edema and focal hemorrhage Congestion, edema and focal hemorrhage Moderate diffuse vacuolar (hydropic) hepatopathy Diffuse lymphoid reactive hyperplasia Moderate multifocal chronic membranous glomerulonephritis with lymphoid follicle formation
PR 17/12 NSLO NSLO Moderate multifocal acute alveolar hemorrhage and edema Moderate diffuse vacuolar (hydropic) hepatopathy; Moderate multifocal neutrophilic portal hepatitis Mild diffuse lymphoid reactive hyperplasia Congestion
PR 17/13 Mild focal hemorrhage Mild multifocal acute myocyte degeneration Mild multifocal acute interstitial pneumonia Marked multifocal chronic proliferative cholangiohepatitis with marked cholestasis and necrosis; Extramedullary hematopoiesis Multifocal acute necrotizing splenitis; Extramedullary hematopoiesis. NSLO
PR 17/14 Congestion NSLO Moderate multifocal subacute interstitial pneumonia with bronchiolitis NSLO Moderate lymphoid depletion NSLO
PR 17/15 NE NSLO Autolysis NSLO NSLO Mild multifocal chronic interstitial nephritis
PR 17/16 Congestion Minimal focal chronic lymphocytic infiltrate; Congestion Diffuse atelectasia; Mild multifocal subacute suppurative bronchopneumonia Mild multifocal chronic lymphocytic pericholangitis; Mild diffuse vacuolar (hydropic) hepatopathy NE Mild multifocal chronic lymphocytic interstitial nephritis; Mild multifocal acute tubular degeneration
PR 17/18 Minimal focal lymphocytic vascular cuffing; Congestion and multifocal alveolar hemorrhage Mild multifocal myocardial fibrosis; Mild multifocal acute myocyte degeneration with contraction band necrosis Multifocal acute alveolar hemorrhage Mild multifocal chronic eosinophilic and lymphoplasmacytic cholangitis with intraductal adult trematodes, bile duct hyperplasia and mild fibrosis Mild diffuse lymphoid reactive hyperplasia and sinus histiocytosis Mild multifocal chronic lymphoplasmacytic interstitial nephritis; Mild multifocal segmental membranous glomerulonephritis with proteinuria; Mild multifocal acute tubular necrosis
PR 17/19 Multifocal acute hemorrhage and congestion. NSLO Congestion, edema and multifocal acute alveolar hemorrhage; Focal interstitial nodular lymphohistiocytic and eosinophilic infiltrate Mild multifocal chronic lymphoplasmacytic pericholangitis Diffuse lymphoid reactive hyperplasia and histiocytosis Moderate diffuse global chronic membranoproliferative glomerulitis with moderate lymphoplasmacytic interstitial nephritis; Focal granuloma.
PR 17/20 NE NSLO Locally extensive alveolar hemorrhage; Moderate focal acute suppurative bronchopneumonia Mild diffuse vacuolar (hydropic) hepatopathy NSLO NSLO
PR 17/21 Mild focal chronic lymphocytic meningitis Congestion Diffuse congestion, edema and atelectasia; mild alveolar hemosiderosis Mild multifocal chronic lymphoplasmacytic and granulomatous pericholangitis with mild hemosiderosis; Mild multifocal acute single cell hepatocellular necrosis Mild diffuse lymphoid reactive hyperplasia and mild sinus histiocytosis Mild multifocal acute tubular degeneration with proteinosis e atrofia glomerulocística focal
PR 17/22 NSLO NSLO Diffuse congestion, edema and multifocal acute hemorrhage; Multifocal atelectasia; Mild lymphoplasmacytic peribronchial and perivascular infiltrates with rare alveolar multinucleate giant cells Mild multifocal chronic lymphoplasmacytic and eosinophilic cholangiohepatitis with moderate bile duct hyperplasia; Mild diffuse vacuolar (hydropic) hepatopathy Moderate diffuse lymphoid reactive hyperplasia and sinus histiocytosis Minimal multifocal chronic lymphoplasmacytic interstitial nephritis and rare glomerulocystic atrophy
  1. NSLO: no significant lesions observed; NE: not evaluated.