Figure 3: | Scientific Reports

Figure 3

From: Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases

Figure 3

Lyme disease diagnostic tests should incorporate Borrelia burgdorferi sensu stricto, Borrelia afzelii, and Borrelia garinii in spirochetes and persistent forms. (A and B) immunoglobulin M (IgM) and immunoglobulin G (IgG) responses by patients to different forms of Borrelia and other TBD microbes. Patients refer to individuals from categories Centers for Disease Control and Prevention (CDC) acute, CDC late, CDC negative, Post-Treatment Lyme Disease Syndrome (PTLDS), immunocompromised, and unspecific. Other TBD microbes include Babesia microti, Bartonella henselae, Brucella abortus, Ehrlichia chaffeensis, Rickettsia akari, Tick-borne encephalitis virus (TBEV), Chlamydia pneumoniae, Chlamydia trachomatis, Coxsackievirus A16 (CVA16), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Mycoplasma pneumoniae, Mycoplasma fermentans, and Human parvovirus B19 (HB19V). (A.1 and B.1) Distribution of IgM and IgG levels to different species of Borrelia spirochetes and (A.2 and B.2) Borrelia persistent forms. Abbreviations Bb, Ba, and Bg depict Borrelia burgdorferi sensu stricto, Borrelia afzelii, and Borrelia garinii, respectively.