Figure 2: | Scientific Reports

Figure 2

From: Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases

Figure 2

Polymicrobial infections are present at all stages of tick-borne diseases. (A) Overall positive immunoglobulin M (IgM), and immunoglobulin G (IgG) responses by patients to none, one, or multiple microbes. (B) Overall positive IgM and IgG reactions by patients to 20 individual microbes. (C) IgM and IgG responses by individual patient categories to 20 microbes. Patient categories refer to individuals from Centers for Disease Control and Prevention (CDC) acute, CDC late, CDC negative, Post-Treatment Lyme Disease Syndrome (PTLDS), immunocompromised, and unspecific. Additionally, only 2C includes IgM and IgG responses by healthy individuals to 20 microbes. Microbes include Borrelia burgdorferi sensu stricto, Borrelia afzelii, Borrelia garinii, Borrelia burgdorferi sensu stricto persistent form, Borrelia afzelii persistent form, Borrelia garinii persistent form, Babesia microti, Bartonella henselae, Brucella abortus, Ehrlichia chaffeensis, Rickettsia akari, Tick-borne encephalitis virus (TBEV), Chlamydia pneumoniae, Chlamydia trachomatis, Coxsackievirus A16 (CVA16), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Mycoplasma pneumoniae, Mycoplasma fermentans, and Human parvovirus B19 (HB19V).