Figure 1: | Scientific Reports

Figure 1

From: Evaluating polymicrobial immune responses in patients suffering from tick-borne diseases

Figure 1

Patient flow diagram. In total, 509 human serum samples were received from various clinical laboratories. Patient samples that arrived without information regarding TBD related symptoms, clinical test results or the diagnosis by a healthcare professional were excluded (n = 77). Remaining 432 patients were tested for their IgM and IgG responses against 20 microbes associated with TBDs. Further, included patients were organized into seven categories based on their respective clinical pictures that followed the Centers for Disease Control and Prevention (CDC) two-tier diagnosis guidelines for Lyme disease, Infectious Disease Society of America (IDSA) guidelines for Post-treatment Lyme Disease Syndrome (PTLDS), and literature regarding the use of lymphocyte and low CD57 cell count in diagnosing patients for Lyme disease. Patient categories included CDC acute (n = 43), CDC late (n = 43), CDC negative (n = 46), PTLDS (n = 31), immunocompromised (n = 61), unspecific (n = 31), and healthy (n = 177).