Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Long-term safety, health and mental status in men with vasectomy


Vasectomy is an efficient male contraceptive method, but the long-term effects of this technology in a large population are unclear. To investigate the influence of vasectomy on long-term health effects, we recruited 485 men with a vasectomy and 1940 men without vasectomy in China. After obtaining basic information from the Aging Males’ Symptoms (AMS) scale and other questionnaires, peripheral blood was drawn to assess the hormone levels, prostate specific antigen (PSA) and blood biochemistry. Using multiple linear regression analysis, these factors had no relationship with vasectomy except for four factors including the Somatic score (0.31, 0.02 and 0.61) in AMS, SF-36 score (−18.8, −32.00 and −5.60), “Role emotional” (−6.28, −10.34 and −2.22) and “Mental health” (−1.55, −3.08 and −0.02). A stratified analysis showed that with increased age, smoking and drinking, residence in township or a higher level of education, the mental health of men was worse. Vasectomy had no long-term effect on the level of sexual hormones in men, and it did not increase the level of PSA. The impact of the vasectomy on quality of life in men were mainly reflected in psychological effects, which suggests that men with vasectomy groups many benefit from professional psychological counseling.


Vasectomy is a male contraceptive method involving a small operation of the vas deferens. It is a simple, effective and permanent method of male contraception. Globally, approximately 5% of married couples of reproductive age depend on vasectomy as a contraceptive method1. In countries such as China and India, vasectomy is regarded as an extremely popular and safe method of sterilization, especially during the period of the 1960s to 1970s, even though the initially high rate of acceptance has decreased2. Because of the crucial role that vasectomy plays, many studies have attempted to better understand the consequences of vasectomy3,4,5.

Some studies have suggested that the intraluminal pressure of the reproductive tract can damage the testis and epididymis due to the sperm accumulation after vasectomy6. As a consequence, therefore, researchers assessed testosterone levels and testosterone deficient symptoms after vasectomy. The total testosterone level is usually tested in the clinic, although free testosterone is more accurate for assessment7. The testosterone deficiency symptoms are not specific and the questionnaires are designed to assess the symptoms. The AMS (the Aging Male’s Symptoms scale) contains seventeen questions and is used to assess testosterone deficiency symptoms, such as LOH (late onset hypogonadism)8.

A fatal risk factor is the risk of prostate cancer. Previously many studies that focused on assessing the relationship between prostate cancer risks and vasectomy have reported contradictory results9,10,11. Prostate symptoms are assessed by the International Prostate Symptom Score (IPSS) questionnaire12. In addition to testis and prostate-relevant syndromes, as far as we know, little evidence has been provided to estimate the effects on other organs, such as the metabolic illnesses. Additionally, quality of life after the vasectomy was usually ignored in previous studies. Furthermore, post-vasectomy complications have focused on physical complaints, such as post-operative pain13,14. However, evidence suggests that the process may also be associated with by psychological complications, including depression, irritability and somatic symptoms15.

However, these studies are limited. Therefore, it is thus timely to study the long-term safety and mental consequences and to recommend further research on this method of contraception. The aim of this study was to understand the effects of vasectomy over a long-term postoperative period by analyzing of the laboratory parameters and questionnaires.


Characteristics of the subjects

The characteristics of 485 men with vasectomy and 2425 men without vasectomy are shown in Table 1. The age of the two groups is matched with a mean age of 58.3 years. There is no significant difference in weight (P = 0.07), BMI (P = 0.77) or abdomen circumference (P = 0.51) in the anthropometric measures. Smoking status, alcohol intake and education also showed no differences (P = 0.72, P = 0.72, P = 0.92). Compared to men without vasectomy, more individuals with vasectomy lived in villages (P < 0.001). The mean scores of the questionnaires including the AMS, SF-36 and IPSS were the same between the two groups but the mean score of the Beck Depression Inventory was higher in men with vasectomy(P = 0.01).

Table 1 Distribution of potential confounders among men with and without vasectomy.

The sex hormones levels of luteinizing hormone (LH), free testosterone (FT) and the testosterone secreting index (TSI) were not significantly different but total testosterone (TT) was significantly different (P = 0.02) between the vasectomy and non-vasectomy groups. The PSA and free PSA (fPSA) of the vasectomy group were higher than the non-vasectomy group. All the mean values from the blood biochemical tests were in the normal range, but there were significant differences in globin (P = 0.01) were found between the vasectomy subjects and the non-vasectomy subjects.

Association between Vasectomy and Sex Hormones

The relationship between serum sex hormone levels and vasectomy was assessed by multiple linear regression analysis with the enter-model method (Table 2). The results revealed that vasectomy was not associated with the levels of TT, SHBG, cfT, FTI and LH after adjustments for Model 1 (age), Model 2 (model 1 + BMI + weight + AC) and Model 3 (model 2 + smoking and drinking status + education + marriage + residence). To evaluate the association between prostate cancer and vasectomy, PSA, fPSA and fPSA/PSA were also assessed via multiple linear regression analysis. The results showed that the relationship between prostate cancer and vasectomy was exceedingly weak and was not significantly different.

Table 2 Multivariate Linear Regression Analyses for serum sex hormone levels associated with vasectomy.

Multivariate Linear Regression and Analyses of the Relationship between Vasectomy and the AMS and SF-36 scales

According to multiple linear regression analysis, vasectomy is not an independent variable in the models of the total AMS (Table 3). However, one of three aspects of AMS, the Somatic score was associated with vasectomy (0.31, 0.02 and 0.61). Health status was further tested with the SF-36 score and eight additional aspects. The results showed that vasectomy will significantly affect the SF-36 score in Model 4. “Role emotional” −6.28 (−10.34, −2.22) and “Mental health” −1.55 (−3.08, −0.02) were associated with vasectomy. Although these two psychological factors of the SF-36 were changed, vasectomy did not affect the Beck score.

Table 3 Multivariate Linear Regression Analyses for ageing males’ symptoms (AMS) scale associated with vasectomy.

To lend further insight into the involvement of the scales and vasectomy, we determined the positive and negative values according to the score of the scales. The sample was divided into two groups by the thresholds of AMS = 27 or IPSS = 7. According to multiple logistic regression analysis vasectomy is not an effect factor for the AMS scales (P = 0.39, 1.10 (0.89, 1.35)). There is also no relationship between vasectomy and IPSS (P = 0.17, 1.21 (0.92, 1.58)).

Multivariate Linear Regression Analyses of the Relationship between Vasectomy and Blood Biochemistry

To evaluate the effects of vasectomy on metabolism, as shown in Table 4, eight index values were tested and analyzed by multivariate analysis after adjustments for Model 1 (age), Model 2 (Model 1 + BMI + weight + AC), Model 3 (Model 2 + smoking and drinking status + education + marriage + residence) and Model 4 (Model 3 + TT + SHBG + LH). All models indicated that the indexes, including cholesterol, total protein, albumin, high-density lipoprotein, and globulin ratio are not significantly associated with vasectomy.

Table 4 Multivariate Linear Regression Analyses for blood biochemical test associated with vasectomy.

Multivariate Linear Regression Analyses, Stratified by Selected Characteristics

As shown in Table 5, stratified analyses show that there are associations between vasectomy and the health scale. Four significant significantly affected factors by vasectomy included “Somatic score”, “SF-36”, “Role emotional” and “Mental health”, as determined by stratified analyses with Model 4. This analysis suggests that males aged 60 or older might have an increased risk for abnormal health compared to younger males. Men who smoke or drink may also have increased risk of these four factors. More changes were found with residence in township or more education, and this trend can significantly influence the four factors.

Table 5 Multivariate Linear Regression Analyses, Stratified by Selected Characteristics.

Prevalence of Symptoms Related to Vasectomy

Items that were significantly associated with vasectomy were selected. As shown in Table 6, the ordinal responses to the selected questions were then divided into symptomatic and asymptomatic categories. The Mann-Whitney test was used to confirm the differences in testosterone levels between the symptomatic group and the asymptomatic group. The three questions for “Role emotional” were significantly different between the two groups. There were no differences for the other three factors between the symptomatic and the asymptomatic group.

Table 6 Prevalence of Symptoms Related to Vasectomy.


Our study explored the effects of vasectomy through many aspects, and we confirmed that men with vasectomy for over 15 years will not have extended physiological problems, including sex hormones, cancer risk, or physiological rank. However, our results suggest that vasectomy may have psychological effects, such as “psychological symptom, role emotional and mental health”.

We first focused on the level of testosterone after vasectomy. Some researchers found that these symptoms were the result of low androgen levels16,17. In studies of rats, rabbits and monkeys when spermatogenesis was damaged or normal, serum testosterone levels were significantly reduced18. In this study, we did not find a significant change in the total testosterone or free testosterone though a multivariate linear model and the testosterone levels are all in the norm range. These results agree with Xiang’s research, which found no significant difference in testicular or epididymal size via qualitative histology after vasectomy19. Although evidence regarding hormone levels has been conflicting, there is a general consensus that they are within the normal range following vasectomy20. Also we tested FTI and TSI and inferred that the ability of the testis is unaffected after a long-term vasectomy. These results suggest that sperm production and sperm storage/removal might remain balanced after long-term epididymal distension. It is noteworthy that male reproductive hormonal levels may depend on the ethnic differences21. However, we did not analyze the factor that all the participants are East Asian, including a 98.5% (2388/2425) Han Chinese population in this study.

Late-onset hypogonadism (LOH) is a common disorder in older men, but it is often underdiagnosed and untreated22,23. After examining testosterone, we assessed the AMS and found no change in the AMS level. This result suggested that the vasectomy will not increase the risk of LOH. To explore the association between vasectomy and a risk of prostate cancer. By testing the PSA level, some researchers reported an increased prostate cancer risk after vasectomy, especially during a 24-year follow-up study24. However, many other studies and meta-analyses25 found no association between vasectomy and non-vasectomy groups. In our study, we found that evidence of a relationship between prostate cancer risk and vasectomy was not established. A limitation is that we did not perform a digital rectal examination, ultrasound or prostatic biopsy to diagnose prostate cancer.

Currently, research on vasectomy leading to long-term psychological effects is relatively scarce. Ehn. et al.26 evaluated the long-term satisfaction of 108 vasectomized men through a mailed questionnaire 2 and 7 years after the operation. Through retrospective analysis, they found that vasectomy had no major effects on the physical health of men. Another study revealed that sterilization psychologically affected depressive symptoms and anxiety27. Therefore, long-term quality of life assessment and mental status after vasectomy were our key focus. Our results showed that middle-aged and older people are mainly influenced at the psychological level rather than the physiological level after vasectomy. These results may be related to the following factors: First, vasectomy failure occurs in 0–2% of patients28. People were warned that although reversal is feasible, it is not invariably successful. They could be afraid that the procedure may have to be repeated if there are persistent motile sperm in their post-vasectomy semen analysis29. Second, the etiology of post-vasectomy pain syndrome is not clear and pain after vasectomy is a challenging male urological problem. There is no reliable effective treatment, which further frustrates both the patient and clinician because many of these patients will end up seeing physicians across many disciplines30. Third, from the 1970s to 1990s, the Chinese government proposed a population and family planning policy in which the state adopted a series of sterilization measures, including the vasectomy of men with two children. Some of these men received an involuntary vasectomy, and they were not provided preoperative consultation according the vasectomy guideline and policy at that time. They view vasectomy as a symbolic castration, which has led to fears about masculinity, male identity, and the loss of living children. These changes resulted in an adverse effect on psychological adjustment in some men that triggered the onset of depression and anxiety31,32. This outcome may led to a series of psychological problems, while we dot have the information of medical record or specialized examination to support the result.

In addition, potential confounders in the association between men with vasectomy and men without vasectomy have rarely been studied. Our stratified analyses indicated that the SF-36 score and “role emotional” were related to the subject’s age, BMI index, cigarette smoking and drinking status, and educational level. Men after vasectomy of an older age tended to be more susceptible to complications. Mental state and quality of life are easily affected if the men enjoy smoking and drinking. Moreover, stratified analyses indicated that a higher degree of education was inversely correlated with life satisfaction. It is important to note that in this article the overall education level was relatively low. We found that 41.4% of the participant’s education levels were lower than 9 years. We inferred that people with a higher education level would have anxiety because of worry about the success rate, complications, chronic post-operative pain, altered family life and dissatisfaction with the government’s family planning policy. Subahani et al. reported that these complications have generally occurred at higher rates in developing countries, and are linked to limited knowledge about the procedure and inadequate pre-operative counseling. In contrast, encouragement, proper information and good marital relations increased the likelihood of having the procedure performed33.

Consequently, an urgent problem that should be solved is how to reduce psychological problems after vasectomy. In our study, we evaluated the prevalence of symptoms related to vasectomy. A significant difference occurred for role emotional. Psychological distress appears to be due to poor pre-operative counseling on the vasectomy, such as the patients can not get information of the specific type of procedure and anesthesia. In developing countries in particular, there is a limited understanding for vasectomy and negative attitudes have been linked to anxiety about vasectomy34,35. Some participator with vasectomy maybe are excessive fear of a surgical procedure, and they should be record in the pre-operation. The person with Notably our result did not indicate that the vasectomy will cause neurological disorders in the long time. Additionally, the inflammatory and immunological consequences are potential negative effects of a vasectomy. Though some studies explored the inflammatory biomarkers, but there were no sensitive or very specific evidences36. We should explore the reliable biomarkers in the future study.

In conclusion, proper and careful pre-operative counseling is indispensable before vasectomy. Informing men of the safety and the high success rate of vasectomy, as well as the possible immediate and long-term complications, will help to eliminate their anxiety and fear. Meanwhile, psychological counseling for smokers, drinkers, the elderly, and those who underweight individuals are particularly important. They should be counseled that vasectomy will not affect their work efficiency, which should eliminate their doubts in the role emotion questionnaire.

Materials and Methods

Study population

In this study, 4091 community-dwelling Chinese adult men who were aged more than 40 years-old in 3 areas of the Beijing, Hubei and Jiangsu provinces of China were recruited at the local reproductive health services clinic. The trained nurses and investigators introduced the study and after signing an informed consent the participants were invited to complete interviewer-assisted questionnaires, undergo a general physical examination and receive a blood draw for testing. We screened 542 men with a history of no-scalpel vasectomy, then we excluded 27 men because the time since they had their vasectomy was less than 15 years. Among the 515 men, a total of 30 men were excluded for missing demographic information (8 men), missing blood biochemistry test data (13 men) or missing questionnaire data (9 men). The remaining 485 men (154 men from Beijing, 191 men from Hubei and 140 men from Jiangsu respectively) with a history of vasectomy (>15 years) were used as the vasectomy group, and 1940 men (625 men from Beijing, 785 men from Hubei and 530 men from Jiangsu respectively) of the 3549 men without vasectomy were chosen by 1:4 random match according to cluster and age stratified sampling.

The study was approved by the Ethical Committee Review Board of Tongji Medical College, Huazhong University of Science and Technology, China. The experimental protocols were performed according to the approved guidelines. Written informed consents was obtained from all enrolled participants.

Basic information

All participants completed the tables for basic information including age, education level, marital status and residence. Smoking status was classified as never smoked, former smoker and current smoker. Alcohol consumption was classified according to the frequency of alcohol intake, including beer, wine and white spirits, per week. During the health screening, the results of the physical examination were recorded including height, weight, body mass index (BMI), and abdomen circumference. BMI (kg/m2) = [body weight of subject] (kg)/[square of height of subject] (m2).


Three questionnaires (Chinese version), including the AMS, IPSS and SF-36, were completed with interviewer-assistance. The AMS questionnaire included 17 symptoms divided into three groups (psychological, sexual and somato vegetative) and assessed the intensity of andropause symptoms. The International Prostate Symptom Score(IPSS) included three questions regarding filling problems and four questions regarding voiding problems were used to assess prostate symptoms. The SF-36 questionnaire included eight areas (physical functioning, role physical, bodily pain, general health, vitality, social functioning, emotional role, and mental health) and was used to assess the quality of life.

Hormone assays

Blood samples were collected between 08:00 am and 10:00 am. All serum samples were measured in batches in the laboratory center of Wuhan Tongji Reproductive Medicine Hospital. Serum TT, sex hormone-binding globulin (SHBG) and luteinizing hormone (LH) were assayed by chemiluminescent immunoassays on a Beckman Access Immunoassay System (Beckman Coulter, USA). cFT was calculated from TT and SHBG using mass action equations as described by a previous study18. Testosterone secreting Index (TSI) was calculated using the TT/LH equation and free testosterone index (FTI) was calculated using the TT/SHBG equation. Serum concentrations of fasting blood glucose (FBG), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) were measured directly with a Roche combas6000 System (Hoffmann-La Roche Ltd., Sweden).

Blood biochemical test and PSA test

Fasting plasma glucose levels, fasting insulin and serum levels of triglycerides, total cholesterol, total protein, albumin, high-density lipoprotein, and the globulin ratio were measured with a Cobas c311 clinical chemistry analyzer (Hoffmann-La Roche Ltd., Sweden). Reference values were from the SRL Test Dictionary 2004.35. Fasting plasma glucose (fasting blood glucose, FBG) <3.9 mmol/L as hypoglycemia, 3.9–6.1 mmol/L was normal, and >6.1 mmol/L was hyperglycemic. Cholesterol (CHO) <5.72 mmol/L was normal, and ≥5.72 mmol/L was high cholesterol. Triglycerides (triglyceride, TG) at 0.55–1.70 mmol/L was normal, and ≥1.70 mmol/L was high triglycerides. HDL (high density lipoprotein, HDL) ≤0.91 mmol/L was reduced, and 0.91–2.07 mmol/L was normal. PSA was detected by a chemiluminescence immunoassay using an Access 2 Immunoassay System (Beckman Coulter Co., Ltd.).

Statistical analyses

Statistical analyses were performed using SPSS statistical software (version 19.0, SPSS Inc, Chicago, IL). Continuous variables were represented as the mean ± standard deviation (SD) and categorical data were represented by number (n) and percentage (%). Comparisons between the two groups were tested using the independent two sample t-test for continuous variables, and the chi-square test for categorical variables. We used a multivariate linear model with robust regression to associate vasectomy and other indexes. The indexes of TT, SHBG and LH were natural log transformed before a linear model analysis to ensure normality. Logistic regression analysis with a forward selection method was performed to analyze the vasectomy and health status questionnaire. Stratified analyses were performed for age (two categories: 40–59, ≥60 years), BMI (two categories: <25, ≥25 kg/m2), smoking (two categories: non-smoking, ever-smoking), drinking (two categories: non-drinker, ever-drinker) and education (two categories: 0–9, ≥10 years)to compare the association between vasectomy and mental health. All P values were 2-sided. A P value < 0.05 was considered statistically significant.


  1. Schwingl, P. J. & Guess, H. A. Safety and effectiveness of vasectomy. Fertility and sterility 73, 923–936 (2000).

    CAS  Article  Google Scholar 

  2. Baade, P. D. et al. Trends in incidence of childhood cancer in Australia, 1983–2006. British Journal of Cancer 102, 620–626, (2010).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  3. Giovannucci, E., Tosteson, T. D., Speizer, F. E., Vessey, M. P. & Colditz, G. A. A long-term study of mortality in men who have undergone vasectomy. The New England journal of medicine 326, 1392–1398, (1992).

    CAS  Article  PubMed  Google Scholar 

  4. Kovacs, G. T. M. F. & Vasectomy Vasectomy. What are the long-term risks? The Medical journal of Australia 2, 4 (1983).

    Google Scholar 

  5. Farley, T. M., Meirik, O., Mehta, S. & Waites, G. M. The safety of vasectomy: recent concerns. Bulletin of the World Health Organization 71, 413–419 (1993).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Pérez-Marín, C. C., López, R., Domínguez, J. M. & Zafra, R. Clinical and Pathological Findings in Testis, Epididymis, Deferens Duct and Prostate following Vasectomy in a Dog. Reproduction in Domestic Animals 41, 169–174, (2006).

    Article  PubMed  Google Scholar 

  7. Shea, J. L., Wong, P. Y. & Chen, Y. Free testosterone: clinical utility and important analytical aspects of measurement. Adv Clin Chem 63, 59–84 (2014).

    CAS  Article  Google Scholar 

  8. Corona, G., Rastrelli, G., Vignozzi, L., Mannucci, E. & Maggi, M. How to recognize late-onset hypogonadism in men with sexual dysfunction. Asian journal of andrology 14, 251–259, (2012).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  9. Pernar, C. H., Downer, M. K., Wilson, K. M. & Stampfer, M. J. Vasectomy and Risk of Prostate Cancer: How to Weigh Current Evidence. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 35, 1272–1273, (2017).

    Article  Google Scholar 

  10. Mayor, S. Vasectomy is not linked to raised risk of prostate cancer, study finds. Bmj 354, i5080, (2016).

    Article  Google Scholar 

  11. Smith, K. et al. Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Journal of clinical oncology: official journal of the American Society of Clinical Oncology 35, 1297–1303, (2017).

    Article  Google Scholar 

  12. Kok, E. T. et al. The valuation of the International Prostate Symptom Score (IPSS) for use in economic evaluations. European urology 42, 491–497 (2002).

    Article  Google Scholar 

  13. Morris, C., Mishra, K. & Kirkman, R. J. A study to assess the prevalence of chronic testicular pain in post-vasectomy men compared to non-vasectomised men. J Fam Plann Reprod Health Care 28, 142–144, (2002).

    Article  PubMed  Google Scholar 

  14. Morley, C., Rogers, A. & Zaslau, S. Post-vasectomy pain syndrome: clinical features and treatment options. Can J Urol 19, 6160–6164 (2012).

    Google Scholar 

  15. Sandlow, J. I., Westefeld, J. S., Maples, M. R. & Scheel, K. R. Psychological correlates of vasectomy. Fertility and sterility 75, 544–548 (2001).

    CAS  Article  Google Scholar 

  16. Laughlin, G. A., Barrett-Connor, E. & Bergstrom, J. Low Serum Testosterone and Mortality in Older Men. The Journal of Clinical Endocrinology & Metabolism 93, 68–75, (2008).

    CAS  Article  Google Scholar 

  17. Kupelian, V. et al. Low Sex Hormone-Binding Globulin, Total Testosterone, and Symptomatic Androgen Deficiency Are Associated with Development of the Metabolic Syndrome in Nonobese Men. The Journal of Clinical Endocrinology & Metabolism 91, 843–850, (2006).

    CAS  Article  Google Scholar 

  18. Vermeulen, A., Verdonck, L. & Kaufman, J. M. A critical evaluation of simple methods for the estimation of free testosterone in serum. The Journal of clinical endocrinology and metabolism 84, 3666–3672, (1999).

    CAS  Article  PubMed  Google Scholar 

  19. Xiang, Y., Luo, P., Cao, Y. & Yang, Z.-W. Long-term effect of vasectomy on spermatogenesis in men: a morphometric study. Asian journal of andrology 15, 434–436, (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  20. Alexander, N. J., Free, M. J., Paulsen, C. A., Buschbom, R. & Fulgham, D. L. A Comparison of Blood Chemistry, Reproductive Hormones, and the Development of Antisperm Antibodies After Vasectomy in Men. Journal of Andrology 1, 40–50, (1980).

    CAS  Article  Google Scholar 

  21. Eendebak, R. J. et al. Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men. Clin Endocrinol (Oxf) 86, 660–668, (2017).

    CAS  Article  Google Scholar 

  22. Chen, Y. P. et al. The rs5934505 single nucleotide polymorphism (SNP) is associated with low testosterone and late-onset hypogonadism, but the rs10822184 SNP is associated with overweight and obesity in a Chinese Han population: a case-control study. Andrology 4, 68–74, (2016).

    CAS  Article  PubMed  Google Scholar 

  23. Ucer, O. & Gumus, B. The treatment of late-onset hypogonadism. Turk J Urol 40, 170–179, (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  24. Siddiqui, M. M. et al. Vasectomy and risk of aggressive prostate cancer: a 24-year follow-up study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 32, 3033–3038, (2014).

    Article  Google Scholar 

  25. Liu, L. H. et al. Vasectomy and risk of prostate cancer: a systematic review and meta-analysis of cohort studies. Andrology 3, 643–649, (2015).

    CAS  Article  PubMed  Google Scholar 

  26. Ehn, B. E. & Liljestrand, J. A long-term follow-up of 108 vasectomized men. Good counselling routines are important. Scandinavian journal of urology and nephrology 29, 477–481 (1995).

    CAS  PubMed  Google Scholar 

  27. Lyons, H. A. Psychological screening for vasectomy. The Ulster Medical Journal 47, 177–185 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Awsare, N. S., Krishnan, J., Boustead, G. B., Hanbury, D. C. & McNicholas, T. A. Complications of vasectomy. Annals of the Royal College of Surgeons of England 87, 406–410, (2005).

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kenogbon, J. I. Evidence-based counselling for vasectomy. International journal of clinical practice 54, 317–321 (2000).

    CAS  PubMed  Google Scholar 

  30. Tan, W. P. & Levine, L. A. An overview of the management of post-vasectomy pain syndrome. Asian journal of andrology 18, 332–337, (2016).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  31. Goldstuck, N. D., England, M. J. & Dukes, I. A. Attitudes to vasectomy among rural and urban African men. 4(2–3), 235–241 (1988).

  32. Dibaba, A. Rural men and their attitude towards vasectomy as means of contraception in Ethiopia. Trop Doct 3 (2001).

  33. Shaik, S. & Rajkumar, R. P. Post-vasectomy depression: a case report and literature review. Mental illness 6, 5494, (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  34. Philliber, S. G. & Philliber, W. W. Social and psychological perspectives on voluntary sterilization: a review. Studies in family planning 16, 1–29 (1985).

    CAS  Article  Google Scholar 

  35. Saoji, A, Gumashta, R., Hajare, S. & Nayse, J. Denial Mode for Vasectomy among Married Men in Central India: Causes and Suggested Strategies. J Psychol Psychother 07 (2013).

  36. Coady, S. A., Sharrett, A. R., Zheng, Z. J., Evans, G. W. & Heiss, G. Vasectomy, inflammation, atherosclerosis and long-term followup for cardiovascular diseases: no associations in the atherosclerosis risk in communities study. The Journal of urology 167, 204–207 (2002).

    Article  Google Scholar 

Download references


We thank the men who participated in the three areas. The study was supported by the Ministry of Science and Technology of the People’s Republic of China (2012BAI32B03) and National Natural Science Foundation of China (No. 81370755).

Author information

Authors and Affiliations



Study design: Kai Zhao, Li Wu, Chengliang Xiong; Clinical data acquisition, patient recruitment: Kai Zhao, Li Wu, Xiangbin Kong, Yaoping Chen, Yiqun Gu, Xuejun Shang; The design and implementation of test: Kai Zhao, Honggang Li, Chengliang Xiong; Association study execution: Honggang Li, Yiqun Gu, Xuejun Shang; Statistical data analysis: Kai Zhao, Li Wu, Honggang Li; Critical discussion on data interpretation: Kai Zhao, Li Wu, Yiqun Gu, Xuejun Shang, Chengliang Xiong; Manuscript drafting: Kai Zhao, Li Wu; Comments to early versions of the manuscript: Kai Zhao, Li Wu, Chengliang Xiong; Critical revision for important intellectual content: Kai Zhao, Li Wu; All authors have approved the final version of the manuscript. As the first authors, Kai Zhao, Li Wu are equally contributing authors.

Corresponding author

Correspondence to Chengliang Xiong.

Ethics declarations

Competing Interests

The authors declare no competing interests.

Additional information

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zhao, K., Wu, L., Kong, X. et al. Long-term safety, health and mental status in men with vasectomy. Sci Rep 8, 15703 (2018).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Somatic Score
  • Emotional Role
  • Professional Psychological Counseling
  • Male Contraceptive Method
  • International Prostate Symptom Score (IPSS)


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing