Figure 1 | Scientific Reports

Figure 1

From: Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

Figure 1

The microfluidic device at a glance. (a) Cross-sections of the HMOC. The right cross-section illustrates the tumour (1) and skin (2) microtissue compartments schematically. The left cross-section shows the interrelationship between the compartments and the microparticle imaging points (A–C). The peristaltic three-valve micropump lies between A and B. (b) Relationship between frequency and average flow rate at three different pressures (n = 10 for each data point). A linear factorial model was generated from the data acquired and extrapolated to 2 Hz (dashed lines). (c) Wall shear stress at the surface of the tumour microtissues and at the base of the skin Millicell® standing insert (colours in dyn/cm2) and streamlines (black lines) in the chip.

Back to article page