We report the photochemical carboxylation of o-phenylenedimamine in the absence of a base and an electron donor under an atmosphere of CO2, which afforded 2,3-diaminobenzoic acid (DBA) in 28% synthetic yield and 0.22% quantum yield (Φ(%)). The synthetic yield of DBA in this reaction increased to 58% (Φ(%) = 0.47) in the presence of Fe(II). The photochemical reaction described in this work provides an effective strategy to use light as the driving force for the direct carboxylation of organic molecules by CO2.
Owing to the ever-increasing desire to use carbon dioxide (CO2) as an C1 feedstock1,2,3,4,5,6, the development of heterogeneous5,7 and homogeneous4,8,9,10,11,12,13,14,15,16,17,18,19,20,21 catalysts for the transformation of CO2 into reduced C1 compounds8,9,17,18,19,20,21 or CO2-containing organic compounds has received considerable attention10,11,12,13,14,15,16. In the former case, several thermal hydrogenation8,9, electro-17,18,19, and photo-catalytic systems17,18,20,21 that produce reduced C1 chemicals, e.g., CH3OH22,23,24, CO25,26,27,28,29,30, HCO2H31,32,33, and HCO2−34,35,36 have been investigated. In the latter case, carboxylic acids are formed, which represent a central motif in a variety of synthetically important chemicals37,38,39,40,41,42,43,44,45,46,47,48,49,50.
Recently, the direct carboxylation of aryl rings has garnered considerable attention. For example, Nolan et al. reported the [M(IPr)(OH)] (M = CuI or AuI, IPr = 1.3-bis(diisopropyl)phenylimidazol-2-ylidene)-catalyzed carboxylation of halogenated benzene using KOH or CsOH as a base under an atmosphere of CO242,43. Iwasawa et al. also reported the Pd(OAc)2-catalyzed photochemical carboxylation of aryl halides using [Ir(ppy)2(dtbpy)][PF6] (λex = 425 nm; dtbpy = 4,4′-di-tert-butyl-2,2′-bipyridyl) as the photosensitizer and iPr2NEt as a sacrificial electron donor under CO247. In these reports, the presence of a base and/or electron donor is necessary for the thermal or photochemical reaction and the incorporation of CO2. However, obtaining carboxylic acids directly from CO2 in the absence of an electron donor and base would be more attractive in terms of atom- and step-economy.
We have recently reported the photochemical hydrogen evolution (PHE) from the Fe(II) complex [FeII(opda)3][ClO4]2 (1; opda = o-phenylenediamine) (Fig. 1) under N251, wherein opda acts as a photo-responsive proton/electron pool that forms the partially oxidized semi-benzoquinodiimine (s-bqdi) or o-benzoquinodiimine ligands. The photochemical reaction of 1 under N2 inspired us to investigate that under CO2. Herein, we report the first example for a direct photochemical carboxylation of C–H bonds in aromatic diamines with CO2 in the absence of an electron donor and base.
Photochemical hydrogen evolution reactions from opda and 1 under N2 or CO2
The UV-Vis spectra of opda and 1 in THF under N2 or CO2 (Fig. 2a) exhibit absorption band at 298 nm, attributable to the ππ* transition of opda and a transition with ππ* character of 151. In the case of opda, spectral differences were not observed under N2 or CO2, indicating a negligible effect of the atmosphere on the electronic state. Even though the molar absorption coefficient of 1 changed slightly from N2 to CO2 (Fig. 2a), the similarity of the spectra and the fact that the same colorless crystals of 1 were obtained from THF/n-hexane under each atmosphere (Supplementary Fig. 1 and Supplementary Table 1) indicate that 1 is stable under both gases. When the solution was left to stand for 8 h under CO2, there were virtually no UV-Vis spectral differences in both opda and 1 (Supplementary Fig. 2), demonstrating their stability in the dark. The 1H NMR (THF-d8) spectra of opda under N2 or CO2 (Supplementary Fig. 3) show characteristic signals at 6.42, 6.50, and 3.80 ppm, assignable to aromatic C–H and N–H protons. On the other hand, the spectra of 1 under N2 or CO2 (Supplementary Fig. 3) did not show any clear signals, reflecting its paramagnetic nature51. Aromatic amines afford carbamic acids or benzimidazol-2-one from the reaction with CO2 under basic conditions52,53 or in the presence of catalysts54,55,56. However, such products could not be detected under these dark conditions.
When a THF solution of opda was irradiated with UV light (λex = 300 ± 10 nm) under N2, PHE was observed with an apparent quantum yield of ΦH2@N2(%) = 1.28 × 10−3 (8 h) (Fig. 2b). Contrastively, the amount of evolved hydrogen under CO2 decreased by one third under N2 (ΦH2@CO2(%) = 4.16 × 10−4) (8 h). Under these conditions, a THF solution of 1 also showed PHE with ΦH2@N2(%) = 0.0138 (8 h) and ΦH2@CO2(%) = 3.56 × 10−3 (8 h) (Fig. 2b). The observed inhibitions of the PHE under CO2 clearly suggest an alternative photochemical process under CO2 compared to that under N2.
Direct photochemical carboxylation of aromatic diamines with CO2 by opda and 1
The UV-Vis spectra of opda and 1 after photo-irradiation (8 h) under CO2 showed new absorption band at 347 nm (Fig. 3a). It is noteworthy that the new band was observed only when the photoreaction took place under CO2 (Supplementary Fig. 2). Interestingly, the absorbance of the new bands was significantly increased for 1 relative to opda, which confirms the promoting effect of the Fe(II) ion in 1. The 1H NMR (CD3CN) spectrum after the photoreaction of opda under CO2 (Supplementary Fig. 4) exhibits two sets of doublets at 6.82 and 7.30 ppm, as well as a triplet at 6.51 ppm, suggesting the formation of a 1,2,3-trisubstituted benzene. A similar spectrum was observed after the photoreaction of 1 under identical conditions (Supplementary Fig. 4). X-ray diffraction analysis of the pale yellow crystals of the product unambiguously identified 2,3-diaminobenzoic acid (DBA) (Fig. 3b and Supplementary Fig. 5, Supplementary Tables 2 and 3)57,58. Interestingly, one ortho C–H bond relative to an amino group was carboxylated. The similarity between the UV-Vis and 1H NMR spectra of commercial DBA and the photochemical products of opda or 1 (Fig. 3a and Supplementary Fig. 6) indicates that DBA is the main product, while the isomer, i.e., 3,4-diaminobenzoic acid, was not obtained in detectable amounts. Based on the molar absorption coefficient of DBA (ε = 4,041 M−1 cm−1) at 347 nm (Fig. 3a), the photochemical reaction of 1, prepared in-situ by mixing [FeII(H2O)6][ClO4]2 and 3 eq. of opda (run 3 in Table 1), afforded DBA in 58.0% (Φ(%) = 0.47), which is comparable to that for ex-situ-prepared 1 (54.1%; Φ(%) = 0.44) (Supplementary Fig. 7 and run 1 in Table 1). On the other hand, the photo-irradiation of a THF solution of opda afforded DBA in 27.5% (Φ(%) = 0.22) (Fig. 3a and run 4 in Table 1).
A reaction mechanism for the photochemical carboxylation
To get insight into the underlying reaction mechanisms, we subsequently carried out the photoreaction with aniline and Fe(II) under CO2. However, the UV-Vis spectrum showed no significant changes (Supplementary Fig. 8 and run 5 in Table 1). The inertness of aniline prompted us to use m- (mpda) and p-phenylenediamine (ppda)59,60. The photo-irradiations (λex = 300 ± 10 nm) of mpda or ppda resulted in the emergence of new absorbances at 360 nm and 400 and 450 nm, respectively (Supplementary Fig. 9, runs 6 and 8 in Table 1). Curiously, the absorbances of mpda and ppda were observed even after irradiation, suggesting their poor reactivity (Supplementary Fig. 9). ESI-MS spectra showed signals (m/z 151.05) for the carboxylated products in the crude reaction mixture (Supplementary Figs 10a and 11a). The newly emerged 1H NMR signals of the carboxylated products were assigned to 2,4- and 2,5-diaminobenzoic acids (Supplementary Figs 10b and 11b). Conversely, the treatment of mpda or ppda with Fe(II) afforded white precipitates, probably due to the formation of coordination polymers (runs 7 and 9 in Table 1)61,62.
Given the atmosphere-dependent photoreactions of opda and 1, we focused our attention on their excited states. The emission spectra (λex = 300 nm) of opda and 1 in THF under N2 or CO2 showed the emission bands at 350 nm, assignable to emissions from ππ* of opda or ππ* included excited state of 1 (Supplementary Fig. 12). In the excitation spectra of opda and 1 under N2 or CO2 (λobs = 350 nm), the bands were observed at 298 nm, suggesting radiative deactivation pathways for the photoreactions under N2 and CO2 (Supplementary Fig. 13).
Subsequently, we attempted to identify the active species by trapping experiments. It was previously reported that 2-methylpropane-2-thiol (t-BuSH) can act as a hydrogen (H) radical scavenger forming di-tert-butyl disulfide (t-Bu2S2)63,64. The detection of t-Bu2S2 among the photochemical reaction products of opda and 1 revealed the H radical generation during the reaction (vide infra). The 1H NMR spectra of t-BuSH and t-Bu2S2 under CO2 (Fig. 4a,b, and Supplementary Fig. 14) showed singlets at 1.38 and 1.29 ppm, respectively. On the other hand, we found that the new signals emerged at 0.88, 0.89, and 1.19 ppm in the 1H NMR spectrum of a THF-d8 solution of t-Bu2S2 after photo-irradiation (λex = 300 ± 10 nm), which demonstrates the photoreactivity of t-Bu2S2 (Fig. 4c)63. These resonances are thus indicative of the in-situ formation of t-Bu2S2. A mixture of opda/t-BuSH displayed a 1H NMR spectrum similar to those of pure t-BuSH and opda (Fig. 4d and Supplementary Fig. 14), suggesting negligible interactions in the ground state. After photo-irradiation, new singlets emerged at 0.88, 0.89, and 1.19 ppm (Fig. 4e), and these peaks are identical to those of the photochemical products derived from t-Bu2S2 (Fig. 4c), suggesting the formation of t-Bu2S2 during the photochemical reaction. The 1H NMR spectrum of a mixture of 1/t-BuSH showed no significant interaction in the ground state (Fig. 4f), whereas new singlets emerged at 0.88 and 4.61 ppm after photo-irradiation (Fig. 4g and Supplementary Fig. 14). These peaks are comparable to those of the photochemical products of opda/t-BuSH mixture (Fig. 4e), suggesting the formation of t-Bu2S2 from 1/t-BuSH. Based on these results, it should be feasible to consider a reaction pathway involving the H radical generation for the photoreaction of opda and 1 under CO2. The lower amount of photochemically generated H2 from them under CO2 than N2 thus most likely reflects the incorporation of the generated H radicals in the DBA skeleton.
Finally, to shed more light on the reaction mechanism, we compared the 13C NMR (CD3CN) spectra of the reaction product of 1 under CO2 or 13CO2. In the 13C NMR spectrum of the photochemically-produced DBA from 1 under CO2, the resonance derived from the carboxyl carbon was observed at 170.5 ppm (Fig. 5a). In the case of the photoreaction under 13CO2, the peak intensity of the carboxyl carbon clearly increased, suggesting that the carboxyl moiety in DBA originates from CO2 (Fig. 5b)14,65.
Figure 6 depicts plausible mechanisms for the photochemical carboxylation of opda and 1. Given the aforementioned results, the photo-irradiation induces the generations of H and aminyl radical intermediates. The later then form a C–C bond with CO2 via the delocalization of the unpaired electron, thus forming the carboxyl radical intermediate66. Subsequently, the methine proton transferrs to the imino nitrogen, whereby the aromatic stabilization could act as driving force forming a 2,3-diaminobenzoic radical species. The reaction of the intermediate with a H radical might finally yield DBA. The role of the Fe(II) ion in this reaction should be worth investigating in detail, as it is highly plausible that the Fe(II) center perturbs the N–H moiety in opda favorably64,67,68,69,70,71.
In this paper, we demonstrated a direct photochemical C–H carboxylation of aromatic diamines with CO2. Although this reaction is not catalytic, it represents the first example of atom- and step-economic direct carboxylation of a C–H bond in benzene rings in the absence of any potentially reactive electron donor and base. The promotion of this reaction by Fe(II) could be achieved using opda ligand, indicating the potential of nonprecious metal ions to accelerate or catalyze the reaction. Further efforts to gain an in-depth understanding of the mechanism and to expand the scope of the reaction by using a wider range of aromatic polyamines, nonprecious metal ions, excitation wavelengths, and catalytic protocols are currently in progress.
All synthetic operations were performed under N2 or CO2 using standard Schlenk-line techniques. The ligand opda was purchased from Wako Pure Chemical Industries (Japan), while p-phenylenediamine (ppda) was obtained from Sigma-Aldrich, and m-phenylenediamine (mpda), was procured from Tokyo Chemical Industry Co., Ltd. (Japan). 2,3-Diaminobenzoic acid (DBA) was purchased from Combi-blocks (USA) and used after recrystallization from H2O. Dehydrated THF, THF-d8, CD3CN, and silica gel (60 N) were purchased from Kanto Chemical Co. Inc. (Japan). MeOH, CH3CN, and emission analysis grade THF were obtained from Nacalai Tesque, Inc. (Japan). N2, CO2, and 13CO2 were purchased from Kotobuki Sangyo Co. Ltd. (Japan). Prior to use, THF was degassed by at least five freeze-pump-thaw cycles, followed by N2 or CO2 sparging for 20 min, and subsequent dehydration over molecular sieves (4 Å, MS4A), which were purchased from Wako Pure Chemical Industries (Japan) and activated by heating under high vacuum. Complex [FeII(opda)3][ClO4]2 (1) was prepared according to a previously reported procedure51. Caution! Although we did not experience any difficulties manipulating perchlorate salts, these should be regarded as potentially explosive and therefore require handled with the utmost care.
UV-Vis-NIR spectra were recorded on a HITACHI U-4100 spectrophotometer at room temperature (25 °C). IR spectra were recorded on a Thermo Nicolet 6700 FT-IR spectrometer by attenuated total reflection (ATR) method. 1H and 13C NMR (500 and 126 MHz) spectra were recorded on a JEOL EX-500 (and A-500) spectrometer using CD3CN or THF-d8. Elemental analyses were carried out on a Perkin-Elmer 2400 II CHN analyzer. Electrospray ionization mass spectra (ESI-MS) were performed at the Global Facility Center at Hokkaido University. Emission and excitation spectra were recorded on a Horiba FluoroMax-4 spectrophotometer at room temperature (25 °C).
Preparation of the solutions used for the reactions under atmospheres of N2 or CO2 (in the dark or under irradiation)
The sample solutions for reactions under N2 or CO2 were prepared under the respective atmospheres. A colorless THF solution (2.0 mM) of ex-situ-prepared [FeII(opda)3][ClO4]2 was obtained from dissolving [FeII(opda)3][ClO4]2 (6.51 mg, 1.0 × 10−5 mol) in THF (5 mL). On the other hand, in-situ-prepared [FeII(opda)3][ClO4]2 was obtained from the treatment of [FeII(H2O)6][ClO4]2 (3.63 mg, 1.0 × 10−5 mol) with opda (3.24 mg, 3.0 × 10−5 mol) in THF (5 mL). In a similar manner, a colorless THF solution of a mixture of [FeII(H2O)6][ClO4]2 and aniline was prepared using aniline (2.73 µL, 3.0 × 10−3 mol) instead of opda. THF solutions (6 mM) of FeII-free opda, aniline, mpda, or ppda were prepared by dissolving opda (3.24 mg, 3.0 × 10−5 mol), aniline (2.73 µL, 3.0 × 10−3 mol), mpda (3.24 mg, 3.0 × 10−5 mol), or ppda (3.24 mg, 3.0 × 10−5 mol) in THF (5 mL).
To investigate the reactivity under photo-irradiation, 0.4 mL of the respective sample solutions were transferred into a N2- or CO2-filled 1 mm quartz cell and the UV-Vis spectrum of the initial state was measured. The remaining 4 mL of the sample solution were then transferred into a custom-made Schlenk-flask-equipped quartz tube (volume: 164 mL). After exposing this apparatus for 8 h to photo-irradiation, 0.4 mL of the sample solution were withdrawn and transferred into a N2- or CO2-filled 1 mm quartz cell in order to measure the UV-Vis spectrum. In order to examine the reactivity in the dark, 0.4 mL of the solution were transferred into a N2- or CO2-filled 1 mm quartz cell and the UV-Vis spectrum of the initial state was measured. After allowing the sample solutions to stand for 8 h, in the dark, the spectral measurements were recorded again.
Photochemical hydrogen evolution
For the photochemical hydrogen-evolution reaction (HER), the aforementioned Schlenk-flask-equipped quartz tube (volume: 164 mL) and THF solutions (4 mL) were used. The light source for the photochemical reactions was a 200 W Hg-Xe lamp (LC-8, Hamamatsu Photonics K.K.), and the intensity of the light was measured by using a power meter (Nova, Ophir Optronics Ltd.) and a thermopile sensor (3 A, Ophir Optronics Ltd.) prior to photo-irradiation experiments. Gas chromatographic analyses were conducted using a Shimadzu gas chromatograph (GC-2014) equipped with a thermal conductivity detector (TCD), a column filled with 5 Å molecular sieves, and Ar as the carrier gas (15.0 mL/min). The oven temperature was maintained at 100 °C, while the column and detector temperatures were set to 70 °C and 200 °C, respectively. Before the photo-irradiation experiments, a gas sample (0.3 mL) was collected from the headspace using a gas-tight syringe (Tokyo Garasu Kikai Co. Ltd) and analyzed by GC to confirm the successful N2 or CO2 purge. The samples were then exposed to irradiation in a water bath at room temperature. During the reaction, gas samples (0.3 mL) were collected from the headspace in order to determine the amount of H2 evolved as a function of the irradiation time.
Purification of DBA after the photoreactions
After the reactions in the dark or upon photo-irradiation, as well as measurements of UV-Vis spectra of the samples after the reaction, all THF solutions were transferred into a Schlenk flask and THF was removed under reduced pressure. After measuring of the 1H NMR and ESI-MS spectra, the reaction mixtures were purified by flash column chromatography (Isolera One ACITM Spektra, Biotage Co. Ltd.) on silica gel (60 N; Kanto Chemical Co. Inc.; eluent: CH3CN:MeOH = 9:1 then 0:10). The photochemical products of [FeII(opda)3][ClO4]2 or FeII-free opda were collected and dried in vacuo. The formation of DBA was confirmed by recording the 1H NMR spectra in CD3CN. Colorless single crystals of DBA suitable an X-ray crystallographic analysis were obtained from a recrystallization from THF/n-hexane.
Calculation of the quantum yields (Φ%)
The THF solutions of the samples, except for those of aniline and a mixture of aniline and [FeII(H2O)6][ClO4]2, were exposed to photo-irradiation (λex = 300 ± 10 nm) from a Hg-Xe lamp equipped with the LX0300 band pass filter (Asahi Spectra Inc.; λ = 300 ± 10 nm; half bandwidth = 10.40 nm). The THF solutions of aniline and a mixture of aniline and [FeII(H2O)6][ClO4]2 were exposed to photo-irradiated (λex = 289 ± 10 nm) from a Hg-Xe lamp equipped with a CWL289 nm filter (OptoSigma Corporation, λ = 289 ± 10 nm, half bandwidth = 10 nm). The amount of DBA formed in runs 1, 3, and 4 (Table 1) in the subsequent 8 h were used to calculate the apparent quantum yield (Φ) using Eq. 1.
where, Ne refers to the number of reacted electrons, NDBA to the number of molecules of DBA formed in the reaction, and Np to the number of incident photons.
The X-ray crystallographic coordinates for the structure of DBA reported in this Article has been deposited at the Cambridge Crystallographic Data Centre (CCDC), under deposition number CCDC-1826028. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via http://www.ccdc.cam.ac.uk/data_request/cif.
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The authors are grateful to Prof. Tamejiro Hiyama, Prof. Youichi Ishii, Prof. Masa-aki Haga, Dr. Yasunori Minami, and Dr. Takuya Kuwabara (Chuo University) for their support with the crystallographic analysis, elemental analyses, as well as emission spectral measurements. This work was funded by JSPS KAKENHI grants JP17H04871, JP16K13967, and JP16H04123, as well as MEXT KAKENHI grant JP17H05382 (Coordination Asymmetry) and JP18H05517 (Hydrogenomics), JST, PRESTO grant JPMJPR16SA, the Noguchi Institute, and the Research Promotion Fund from the Promotion and Mutual Aid Corporation for Private Schools of Japan.
The authors declare no competing interests.
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Matsumoto, T., Uchijo, D., Koike, T. et al. Direct Photochemical C–H Carboxylation of Aromatic Diamines with CO2 under Electron-Donor- and Base-free Conditions. Sci Rep 8, 14623 (2018). https://doi.org/10.1038/s41598-018-33060-3
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