Figure 2 | Scientific Reports

Figure 2

From: Humanization of Antibodies using a Statistical Inference Approach

Figure 2

Boxplot of three score distributions for the different datasets: Panel (a): MG score; Panel (b): Tall score; Panel (c): T20 score. Pharmaceutical antibodies are indicated according to the suffix in their International Nonproprietary Name: “umab” are fully human antibodies; “zumab” are humanized antibodies, usually containing murine CDRs grafted on top of human framework variable regions; “ximab” are chimeric antibodies, obtained by assembling the whole murine variable region on top of a human constant part; “omab” are murine antibodies. Since we deal with just the antibodies’ variable regions, “ximab” and “omab” are indistinguishable. The horizontal lines signal the threshold score above (for the MG case) or below (for the other cases) which the sequence is classified as human. The threshold values are \({t}_{MG}=6383\), \({t}_{{T}_{all}}=116\), \({t}_{{T}_{20}}=76\).

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