Figure 7 | Scientific Reports

Figure 7

From: Histone H3K9 demethylase JMJD2B induces hepatic steatosis through upregulation of PPARγ2

Figure 7

Gomisin N (GN) represses the expression of JMJD2B, PPARγ2, and PPARγ2 steatosis target genes in HepG2 cells. HepG2 cells were treated with GN (100 μM) for 12 h. (A) JMJD2B expression was assessed by qPCR and western blotting. The full-length western blots corresponding to truncated blots are given in Supplementary Figure S4. (B) PPARγ2 expression was measured by qPCR. (C,D) The expression of PPARγ2 steatosis target genes was assessed by qPCR. Data represent means ± SEM of three independent experiments performed in triplicate. *p < 0.05 vs. no treatment.

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