Humans are the only species to have evolved cooperative care-giving as a strategy for disease control. A synthesis of evidence from the fossil record, paleogenomics, human ecology, and disease transmission models, suggests that care-giving for the diseased evolved as part of the unique suite of cognitive and socio-cultural specializations that are attributed to the genus Homo. Here we demonstrate that the evolution of hominin social structure enabled the evolution of care-giving for the diseased. Using agent-based modeling, we simulate the evolution of care-giving in hominin networks derived from a basal primate social system and the three leading hypotheses of ancestral human social organization, each of which would have had to deal with the elevated disease spread associated with care-giving. We show that (1) care-giving is an evolutionarily stable strategy in kin-based cooperatively breeding groups, (2) care-giving can become established in small, low density groups, similar to communities that existed before the increases in community size and density that are associated with the advent of agriculture in the Neolithic, and (3) once established, care-giving became a successful method of disease control across social systems, even as community sizes and densities increased. We conclude that care-giving enabled hominins to suppress disease spread as social complexity, and thus socially-transmitted disease risk, increased.
The evolution of care-giving in the human lineage provided our ancestors with an unprecedented ability to modify the progression of diseases through their populations1 and likely had far reaching implications for the evolution of both pathogens and the human immune system. Care-giving would have dramatically altered disease transmission patterns by increasing contacts between infected and susceptible individuals, thus selecting for pathogens that would transmit effectively through these new contact patterns and for a host immune system that is specialized for care-giving. That we are the only species to have evolved widespread, cooperative care-giving for ill individuals suggests that it evolved as a response to conditions that only occurred in the human lineage.
Five decades of research on our closest living relatives, the other apes, have revealed that the human lineage evolved a unique suite of potentially correlated cognitive and social traits2,3,4,5,6,7. After hominins diverged from the rest of the primate order, brain size increased in the human lineage and ancestral capacities for social learning led to greater cumulative culture and increasingly complex technology8,9. A shift to cooperative breeding4,5,10,11,12,13,14 increased the complexity of social networks and is thought to have selected for psychological changes, including greater empathy3,15, the ability to understand the mental states of others, and hyper-cooperation6,7.
Current research16 suggests that this package of cognitive traits may have been key to enabling hominins to recognize when other individuals were sick and in need of care. Detecting disease cues (disease recognition) and processing social information7,8,17,18 use the same neural networks, i.e., face- and odor-perception networks16. When we look at someone’s face or smell their body odors, we glean information about their identity, emotions, and motivations, and simultaneously obtain information about the person’s health status (changes in facial coloration due to fever or rashes, odor changes due to sweating from a fever). The same is likely to be true for voice processing; changes in someone’s voice can alert the listener to respiratory infections. These neural overlaps in disease recognition and social cognition provide compelling evidence that the two evolved together. However, this work also shows that disease recognition must be recognized as cognitively complex independent of social cognition16; in addition to integrating multisensory cues from the respective sensory networks, it involves “superadditive” processing16. This superadditive processing uses cognitive pathways that are not involved when evaluating cues from healthy individuals nor when the visual or the olfactory cues for disease were evaluated individually, providing clear evidence that disease recognition requires complex, multi-level cognitive processing16. For these reasons, we suggest that disease recognition is a previously unrecognized, and crucial, element of the social and cognitive traits that are associated with increasing social complexity in the genus Homo3,6,7,18,19,20.
Cross species studies of nonhuman animals indicate that increased sociality brings intense selection to limit the costs of disease exposure21,22,23, suggesting that the same would have been true of hominins. Recent work in paleogenetics, pathogen genomics, and evolutionary medicine has shown that not only have hominins been infested with numerous pathogens since before the advent of agriculture and animal domestication24,25, but also that their immune defenses were under heavy selection as hominins expanded into new environments, encountered new animal communities26, and hybridized across hominin species acquiring genetic variation at immune loci27,28,29,30,31,32,33. Theoretical and modeling studies indicate that even low levels of relatively ineffective care-giving could have enabled hominins to limit the progression of disease through their populations and reduce the severity of outbreaks1,34,35.
The origins of care-giving are difficult to pinpoint in the fossil record because, although numerous hominin specimens from Homo erectus to H. sapiens bear evidence of recovering from severe illnesses and injuries36,37,38, nonhuman animals survive similar afflictions without care39,40, and care-giving leaves no other fossilized evidence. This means that survival cannot be taken as proof that sick and injured hominins received care. However, regardless of when care-giving evolved, the most parsimonious explanation is that it evolved through pre-existing networks, such as kin networks. Kinship underpins much of primate sociality41 and is the backbone of the networks through which primates care for immatures. Moreover, theoretical and modeling evidence indicates that the inclusive fitness benefits of caring for ill kin mitigates some of the costs of care-giving, making it an evolutionarily stable strategy1,34,35.
The evolution of human social organization, and thus the structure of kin networks, could have either supported or hindered the evolution of care-giving. Here, we simulate the evolution of care-giving for the diseased in a basal primate social system, in which the sole care-giving bonds occur between mother and infant (hereafter basal primate), and compare this with feasibility of the evolution of care-giving in the three leading hypotheses of ancestral human social structure: pair-bonded (pair-bonded)42,43, pair-bonded with indirect reciprocal altruism from a random individual (indirect reciprocity)44,45,46, and cooperative breeding with assistance from kin (kin-based)12,14,47,48. We show that kin-based cooperative breeding, in contrast to the other social systems, likely facilitated the evolution of care-giving in the human lineage, but once effective care was established, care-giving networks would have become more flexible, potentially contributing to the diversity and flexibility of human social systems.
Results and Discussion
We created two models (the Ineffective Care Model and the Effective Care Model) and ran each with each of four social systems (basal primate, pair-bonded, indirect reciprocity, and kin-based, see Table S1. Model code and detailed descriptions are in the Supplementary Files and Text). We provide a brief summary of the two models, the four social systems, then the details of the models.
The Ineffective Care Model simulated the difficulties of establishing care-giving as a method of disease control. It subjected communities of ineffective care-givers to repeated introductions of novel diseases. Each time care was given, the reduction in the recipient’s pathogen replication rate was reduced by a random number less than or equal to the values taken from the literature for that type of care (Table 1). Thus, the benefits of ineffective care both vary randomly and are smaller than the benefits reported in the literature. Novel disease were generated by setting the disease parameters (death rate, transmission rate, and recovery rate) to random numbers within the range expected to maximize care-giving in all social systems (≤0.5)1. As the disease parameters influence how the disease spreads through the population, this creates unique dynamics for each disease. After a disease goes extinct, a novel disease is created with new, randomly selected disease parameters and introduced in the next time step.
The Effective Care Model differed from the Ineffective Care Model by simulating populations in which effective care has been established and systematically varying the disease parameters. Under this model, the benefits of care were fixed at the values found in the literature (Table 1). Disease parameters were varied simultaneously between 0.1 and 0.9 (10%–90%). For example a disease with a severity of 0.1 had a death rate of 0.1, transmission rate of 0.1, and recovery rate of 0.9. When one disease goes extinct, the same disease (with the same disease parameters) is introduced in the next time step. This enabled us to systematically examine the effects of disease parameters over time.
Both models were run with each of four social systems (basal, pair-bonded, indirect reciprocity, and kin-based). In the basal primate social system, care was given only from mothers to offspring. The pair-bonded social system42,43 included parent to offspring care and obligate care between pair-partners. The indirect reciprocity social systems added obligate care from a randomly selected altruist to the pair-bonded care system44,45,46. The kin-based social systems included basal mother-offspring care and care from siblings, grandparents, aunts/uncles, nieces/nephews, and cousins14,47.
The models simulate a hominin community with fission-fusion dynamics in which subsets of individuals are out of contact with other subsets1,49. Community size is limited by four carrying capacity settings: 50, 100, 150, and 200 individuals. This covers reconstructed50 and actual51,52 community sizes for chimpanzees. Moreover, the range of 50–100 individuals covers the range of median community sizes reconstructed for early Homo, H. habilis, H. erectus, H. heidelbergensis, H. neandertalensis, and H. sapiens1,49. The larger community sizes (150, 200) are greater than those predicted for ancestral hominins and are included to investigate the robusticity of care-giving as community sizes increased in the human lineage24. These values encompass the lower range of modern hunter-gather communities (125–200 individuals), including populations on four continents and living in habitats ranging from tropical forest to the Arctic coast53. (We didn’t conduct simulations of larger community sizes, because the simulations that we currently present already suggest that care-giving evolved first in smaller, not larger groups).
With a range of 200 km, our carrying capacities produce densities of approximately 0.25, 0.5, 0.75, and 1 individual/km2, thus approximating the density ranges and confidence intervals predicted for the above Homo species1,49. The initial prevalence of the diseases in the population varied (5%, 25%, 50%, and 75%). All possible parameter combinations were run 100 times for each social system.
In all models the first generation of hominins was assigned heritable intelligence scores. Intelligence is conceptualized as a general ability for efficient information processing54, with more specific cognitive abilities like disease recognition and social learning being aspects of intelligence. When an agent reproduces, the offspring’s intelligence is drawn from a normal distribution with the mother’s intelligence as the mean and a standard deviation of 0.15 (see below for social system specific differences). This represents the 15% standard deviation in the human IQ scale (Table 1). Thus, intelligence of the population changes overtime depending upon whether high or low intelligence individuals are reproducing more rapidly. The ability to recognize when another individual is infected (disease recognition) is an aspect of intelligence and a prerequisite for providing care. Disease recognition does not require that individuals have an abstract concept of disease because it functions on the ultimate level of causation (similarly to how kin recognition operates without individuals requiring an abstract concept of kin).
All carers, except for pair-partners and altruists, cease providing care when the costs exceed the benefits, according to a modified version of Hamilton’s rule55 in which the costs and benefits are expressed in terms of disease risk (infectiousness of the infected individual, death rate of the disease, and recovery rate). When an individual receives care, this reduces that individual’s pathogen replication rate according to an exponential dose-response curve56,57, reducing the individual’s infectiousness, lowering the probability of dying, and increasing the likelihood of recovery. Exponential dose-response curves are used to estimate disease risks in numerous bacterial, protozoal, and viral infections56,57. They require fewer assumptions than other curves, making them appropriate for modeling non-specific diseases56,57. When multiple individuals provide care to the same ill individual (cooperative care), carers can learn additional care-giving skills, with learning being a function of the carer’s intelligence. There are four possible types of care: providing food, water, assistance with hygiene, and protection, with respective reductions in pathogen replication rates based on values from the literature (Table 1). Each sick individual can only receive each type of care once per infection, but individuals do not need to receive all types of care to recover. If a sick individual does not receive all types of care in one time step and remains infected in subsequent time steps, it may receive additional forms of care if its care-giving network expands through population growth, if its carers learn new skills, or if carers who previously failed to recognize the disease later do.
Correspondence between the care-giving rates produced by our models and data from hunter-gather communities suggest that our models have high ecological validity. Data from hunter-gather societies (Ache and Hiwi) shows that on average, breeding pairs with dependents received assistance from 1.3 helpers, including provisions from 0.8 males46. Under the Ineffective Care Model, diseased individuals in the pair-bonded, indirect reciprocity and kin-based systems received care from approximately 1, 1.3 and 1.5 carers (Fig. 1) with slightly higher rates under the Effective Care Model (Fig. S3). Similarly Ache and Hazda individuals, on average, exchange food during injury/illness with 2–3% of the other community members in a given year58. Under the Ineffective Care Model, diseased individuals living in the smallest communities have care-giving relationships with approximately ≤2% (pair-bonded), ≤2.6% (indirect reciprocity), and ≤3% (kin-based) of the community (calculated as the number of carers/carrying capacity of 50 individuals). Though the percentage of dyads with care-giving relationships decreases as community size increases, it also increases under the Effective Care Model (Fig. S3). Overall, our data shows a remarkable similarity to the care-giving patterns reported for hunter-gathers, indicating that the ecological validity of our models is high.
Our results from the Ineffective Care Model demonstrate that the ancestral human social system had a dramatic effect on the feasibility of the evolution of care-giving for the diseased. Social system accounted for most of the variation in cooperative care-giving (88%), even more of the variation in the percentage of infected agents who received care (92%), and a very large proportion of the variance in the mean number of care-giving skills per agent (77%) (Table 2). The effects of social system were much larger than the average effects of community size and initial disease prevalence; although both varied greatly (carrying capacity range: 50–200; initial prevalence range: 5–75%), they accounted for <5% of the variation (r2m in Table 2).
Disease recognition (a prerequisite of care-giving) and social learning of additional care-giving skills are functions of intelligence, so increasing intelligence indicates positive selection for care-giving. This occurred only in the small, kin-based communities (Fig. 2). The decreases in intelligence seen in all other social systems indicate selection against care-giving (Fig. S1). Small kin-based communities produced positive selection for care-giving because care-giving under those conditions suppressed disease spread. Figure 2 shows that the 95% confidence intervals for disease spread in the small, kin-based system overlap with the confidence intervals for the basal primate system. This contrasts with the pair-bonded and indirect-reciprocity curves where disease spread is higher than in the basal system. In the large communities, all social systems show increased disease spread relative to the basal system (Fig. S1). This suggests that as the ancestral human social system evolved from the basal primate system to small communities of kin-based cooperative breeders, care-giving limited diseases from spreading beyond the spread occurring in the basal primate system.
Even though care-giving increases contacts between susceptible carers and infectious individuals, small, kin-based communities had two advantages that made care-giving an effective method of disease control: highly cooperative care and network modularity. Infected individuals received the most care under the kin-based system (Fig. 1), meaning that the cumulative benefit to the infected individual was greater. Carers were also less vulnerable to infection because they shared the costs of care-giving with more carers. Indirect reciprocity provided care to the highest percentage of diseased individuals (Fig. S2), but also had the highest disease spread (Fig. 2). Because altruists provided care regardless of kinship or the risks, they reduced network modularity and increased spread. In contrast, while pair-bonded agents always provided care to their pair partner, the care remained within the kin network. This limited spread relative to the indirect reciprocity networks, but still produced greater spread than in the basal primate system. Thus modularity of the kin networks combined with highly cooperative care, enabled care-giving to become established in the small, kin-based communities as a method of disease control. The modular nature of kin-based care in our models is supported by empirical evidence from the BaYaka foragers. The BaYaka share plant knowledge for medicinal purposes within kin networks, while plant knowledge for foraging and social beliefs is shared more widely among the camp59.
That care-giving was an effective method of disease control when community sizes were small and population densities were low suggests that care-giving evolved before the large, high density communities associated with the advent of agriculture in the Neolithic Age24. The community sizes (~50–100) span the range predicted for the genus Homo and the densities (0.25–0.5 individuals/km2) are generally in the lower ranges predicted for these species1,49. This indicates that kin-based cooperative breeding networks in small, low density hominin communities may have facilitated evolution of care-giving long before the beginning of agriculture in the Neolithic24.
While the Ineffective Care Model simulated the establishment of care-giving in populations which provide ineffective care during repeated introductions of novel diseases, the Effective Care Model simulated populations that give effective care and explored the effects of varying disease severity on the flexibility of the care-giving networks. The reduction in pathogen replication rate produced by each type of care was fixed at the values obtained from the literature (Table 1). The three disease parameters were varied simultaneously between 0.1 and 0.9 in increments of 0.1 (referred to as disease severity in the Effective Care Model). As before, we varied community sizes (small: capped at 50 or 100; large: capped at 150 or 200) and the initial prevalence of the disease (5%, 25%, 50%, and 75%). All parameter combinations were run 100 times for each social system.
The Effective Care Model showed that once effective care is established (benefits fixed at rates in the literature, Table 1), care-giving networks become more flexible in that care-giving is a successful strategy of disease control in pair-bonded, indirect reciprocity, and kin-based networks. Care-giving in the pair-bonded, indirect reciprocity, and kin-based social systems each suppressed disease spread to levels similar to the basal primate system, as shown by the highly overlapping confidence intervals produced by mild diseases across social systems (Fig. 3). Moreover, each of the three social systems with cooperative care produced positive selection for intelligence (reflecting selection for disease recognition, social learning of care-giving skills, and care) in response to diseases with severities of 0.1–0.3 (Fig. 3). However, only the kin-based system maintained positive selection in response to diseases through a severity of 0.4, suggesting that the higher levels of cooperative care in the kin-based social system (Fig. S3) made care-giving in these communities effective with more severe diseases. In the basal primate social system, where care is only given by the mother to the offspring, there is very little selection for disease recognition and thus very little evolution of intelligence (Fig. 3). Overall, the results indicate that once effective care was established in hominin populations, care-giving networks became increasingly flexible, potentially contributing to the evolution of extreme social flexibility in humans.
Over the course of hominin evolution, the greatest selection for increasing intelligence and care-giving would have been produced by high prevalence, low severity diseases. Across the pair-bonded, indirect reciprocity, and kin-based social systems, milder diseases generally produced greater increases in intelligence, reflecting stronger selection for disease recognition, social learning of care-giving, and care. More severe diseases typically produced greater decreases in intelligence, reflecting stronger selection against disease recognition, social learning of care-giving, and care. Figure 4 shows that the negative relationship between disease severity and intelligence is constant across social systems when community size is held constant (rows) and within a social system across community sizes (columns). The colors represent varying disease severities and the order of the colors is largely constant across the panels. Comparisons of the effect sizes across care-giving response variables show that disease severity had a negative effect on cooperative care, the percentage of diseased who received care, and mean number of socially learned care-giving skills (Table 2).
Initial disease prevalence changed the slope of the curves, with higher initial prevalence (up to 50%) producing more positive slopes (columns in Fig. 5). Higher prevalence diseases elicit greater levels of caring and faster population turn-over, generating faster evolution. At an initial prevalence of 75%, care-giving was reduced because only healthy agents gave care. These results indicate that once effective care was established, mild, high prevalence diseases would have selected for increasing intelligence and care-giving in pair-bonded, indirect reciprocity, or kin-based social systems. Additionally, very severe diseases which would have selected against care-giving may have been relatively rare, been self-limiting in low density host populations due to high mortality60, and/or prompted hominins to use other strategies for disease control (i.e., avoidance1,16). Thus, over the course of human evolution, frequent, high prevalence, mild diseases may have had a more sustained effect on care-giving behavior than rare, self-limiting, severe diseases. While it is difficult to reconstruct the virulence of ancient pathogens, several diseases which have persisted in human populations since before the Neolithic24 have similar mortality today to those which produced positive selection in the models (i.e., approximately ≤40% death rate in untreated populations), including whooping cough (≤4% in infants)61, typhoid (12–30%)62, and tuberculosis (≤45%)63.
The Effective Care Model shows that with effective care-giving, disease recognition remains under positive selection even when population densities increase to the upper limits of those reconstructed for ancestral hominin species (1individual/km2) and community sizes typically observed in humans (>100 individuals53). Although larger communities needed longer to eliminate diseases and experienced greater disease spread (positive effect sizes of community size in Table 2), community size had very little effect on the evolution of disease recognition, social learning of care-giving skills, and intelligence (columns, Fig. 4). This suggests that, although care-giving likely evolved in small, low-density, kin-based communities under conditions similar to the Ineffective Care Model, once effective care-giving was established, it remained under positive selection as a mechanism of disease control, even as community sizes and densities increased with the advent of farming and animal domestication in the Neolithic Age24.
The positive feedback loop produced by the correlated evolution of disease recognition and social learning as elements of general intelligence54, is consistent with the idea that care-giving evolved as part of a suite of cognitive and emotional adaptations (enhanced empathy, theory of mind, hyper-cooperation, etc.)3,7 that are associated with the genus Homo, the shift to cooperative breeding4,6,11,13 and caring for altricial infants64. Our results support kin selection55 over reciprocal altruism44 as the driving selection pressure behind care-giving. The kin-based cooperative breeding social system included care from parents, siblings, grandparents, aunts/uncles, nieces/nephews, and cousins14,47 and allowed individuals to cease care-giving when the costs exceeded the fitness benefits specific to the kinship relationship. In contrast, the pair-bonded42,43 and indirect reciprocity systems44,45,46 included, in addition to the basal mother-offspring care and father-offspring care, obligate care between pair-partners and (in the indirect reciprocity system) altruists. The lower levels of cooperative care in the pair-bonded and reciprocity social systems caused the carers to provide risky care without the extended care-giving networks present in the kin-based cooperative breeding social system, thus increasing disease spread beyond the control of care-giving. However, our findings should not be viewed as mutually exclusive with existing hypotheses for the evolution of care-giving (i.e., provisioning by nonkin via indirect reciprocity networks44,45,46); the Effective Care Model indicates that once care-giving was established and individuals provided effective care, pair-bonded networks and reciprocity-based networks would also produce positive selection for disease recognition and care during mild illnesses. This suggests that the indirect reciprocity networks reported in several hunter-gather studies, in which nonkin provision diseased community members in exchange for similar assistance from the community in the future44,45,46, evolved secondarily to care-giving along kin networks.
Moreover, care for the injured44,45,46 should not be viewed as mutually exclusive with care for the diseased. Ancestral hominins probably did not have an understanding of Germ Theory or infectiousness, so providing care for non-infectious individuals (including the injured44,45,46) would have enabled care-giving to occur in situations with zero risk of transmission, likely promoting the practice of care-giving more broadly.
Arguments for human uniqueness have often invoked the cognitive, social, and emotional adaptations that are attributed to the evolution of cooperative breeding in the genus Homo4,6,11,20. Our findings suggest that the combination of these psychological specializations with kin-based cooperatively breeding networks may have provided the scaffolding for the evolution of care-giving for the diseased. Because behavioral responses to disease influence disease transmission patterns, they co-evolve with immune responses34,35. Symptom expression is a result of complex interactions between pathogens and the host immune system34,35. It is intriguing that humans, in contrast to other primates, have lost their body fur65 and have white sclera66 around their eyes, making sores, rashes, fevers, and bloodshot eyes more visible. This may indicate selection on immune responses to display and exaggerate, rather than conceal, symptoms as a mechanism for soliciting care in care-giving contexts34,35. It opens the intriguing possibility that the evolution of care-giving may have created novel selection pressures, selecting for immune responses that are adapted for a care-giving host. Such selection may underlie increases in immune system reactivity in humans relative to other great apes67,68 and may have contributed to the introgression of locally adapted immune genes as the human lineage colonized new habitats and hybridized with other hominin species27,28,29.
On a population scale, our results suggest that care-giving enabled kin-based cooperatively breeding hominins, with increasingly complex contact networks, to prevent disease transmission from increasing with social network complexity. The significance of care-giving as a mechanism of disease control is reinforced by research indicating that care-giving suppresses disease outbreaks more than an avoidance strategy1. During hominin evolution, care-giving likely produced a cascade of novel selection pressures, selecting for psychological changes that would facilitate cooperative care-giving, symptom advertisement for soliciting care, an immune system specialized for care-giving, and pathogens adapted to transmission among care-giving hosts. Care-giving was likely a key element of the psychological and behavioral traits that are associated with the success of the genus Homo2,3,4,5,6,7,8,9, and the ability to suppress disease spread may have been a prerequisite21,23 for the extreme social complexity that evolved in the human lineage.
The world is a grid of 100 × 100 grid cells each of which represents 2 km2, making the community’s range 200 km2. This is within the confidence intervals of the calculated area required for H. erectus, H. heidelbergensis, H. neandertalensis, and H. sapiens1,49. Carrying capacities were set at 50, 100, 150, and 200 individuals to cover communities sizes observed in chimpanzees51,52, reconstructed values for hominins1,49, and values observed in some modern hunter-gather communities53. Reproduction occurs according to the formula:
Females can have a maximum of one offspring per time step. Offspring are placed in a radius of one grid cell of the mother.
Each social system is reduced to its care-giving networks (Table S1), thus the networks are not synonymous with the mating system (see below for a discussion of the mating system in each social system). No attraction rules were used to subdivide the community into subgroups/kin groups or limit movements. At the end of each time step, healthy agents move randomly to an empty grid cell in a radius of 10. If no grid cells are available, the agent stayed. This produces a single, fission-fusion community in which subgroups of individuals are close enough to infect each other and other subgroups are not. The care-giving networks are a result each social system’s input rules for forming bonds between individuals (i.e., kin networks expand as individuals reproduce). Across social systems, networks differ in size and in modularity (the degree to which they are connected to other networks, details for each social system are provided below).
Each model initializes with 10 males and 10 females distributed randomly around the landscape. Each agent starts as uninfected and its personal disease parameters are set to 0: my-shedding (pathogen load), my-probability-transmission, my-probability-fatality, and my-probability-recovery. Each hominin is randomly assigned one of the four possible care-giving skills (providing food, water, hygiene assistance, or protection) and randomly assigned an intelligence score. Intelligence is conceptualized as a general ability for efficient information processing54, with more specific cognitive abilities like disease recognition and social learning being aspects of intelligence. These links between disease recognition, intelligence, and the processing of social information are supported by neurological research demonstrating that disease recognition involves integrating information from the odor and face perception networks16. This indicates that the brain pathways involved in disease recognition overlap with those which process social information from faces and odors16. Moreover, disease recognition does not require that individuals have an abstract concept of disease. Instead disease recognition functions on the ultimate level of causation, similarly to how kin recognition operates without individuals requiring an abstract concept of kin. In our models the hominin intelligence scores range from 0 to 1, thus scaling to the human IQ scores which range from 50 to 150 (Table 1). When an agent reproduces, the offspring’s intelligence is drawn from a normal distribution with the mother’s intelligence as the mean and a standard deviation of 0.15 (see below for social system specific differences). This represents the 15% standard deviation in the human IQ scale (Table 1).
The disease starts when the community reaches ½ of the carrying capacity, enabling the community to reproduce and establish its social network. When the disease begins, a percentage of the population (5%, 25%, 50%, or 75%) is randomly infected. This enabled us to test the effects of initial prevalence on the outcomes of the model. This approach is also logical and relevant to the real world. Depending upon sources and transmission modes, outbreaks vary greatly69. For example, a small number of individuals may have contact with another infectious individual, leading to very low initial prevalences in the population (i.e., tuberculosis transmission, known to be pre-agricultural24). Alternatively, if all community members drink from a contaminated water source (i.e., Salmonella transmission, known to be pre-agricultural24), initial prevalence may be very high. We expect that the evolution of care-giving strategies would have had to be able to cope with both low and high prevalence outbreaks.
We chose to create a spatially explicity model to enable the diseases to transmit through a community spread across a landscape. This represents the spatial component of disease transmission through a population. During an outbreak of a socially transmitted disease, individuals who are physically near infected individuals are more vulnerable than more distant individuals. This produces waves of infections and transmission along social networks22,70,71,72,73. By including a spatial dimension, we demonstrate that our model can cope with these complex dynamics.
We did not connect our population to an external reservoir because the aim of this study was to examine whether care-giving could control highly variable transmission dynamics. If we had connected our population to an external reservoir, it would have constrained the disease transmission dynamics, making it easier for the population to evolve effective care-giving mechanisms. Transmission dynamics can be extremely complex, involving multiple and changing host species, and multiple and changing transmission modes69. Instead of restricting the model, we varied the initial prevalence values across runs while holding the other parameters constant (disease parameters, community size).
When one disease goes extinct, the next starts in the following time step. Each disease has a death rate, transmission rate, and recovery rate. Infected agents set their pathogen load to 1000 (the absolute value is not important, it is a relative value), and set their personal probabilities of transmission, death, and recovery to those of the disease, and set the list of the types of care that they need to be food, water, hygiene assistance, and protection. When an agent is diseased, each agent in its care-giving network undergoes two screening processes, first based on disease recognition and second based on care-giving skills. (Care-giving networks are social system specific, details provided below). The potential carers each draw a random number from 0 to 1. If the number is below the agent’s intelligence score, it correctly identifies the diseased agent as needing care. If the number is above, the agent incorrectly identifies the diseased agent as healthy and will not provide care. Agents that correctly identify the disease are then screened according to whether they have one of the care-giving skills that the agent needs. Care types can only be given once per infection and each carer can only give one type of care to a given agent per time step. If the sick agent remains sick over multiple time steps, the selection process is repeated in each time step. This means that the same carer could provide a different form of care in a subsequent time step if it has more than one care-giving skill or learns another skill. Additionally, because intelligence is a probability of correctly identifying disease in others, carers that previously failed to recognize the disease may do so in subsequent time steps if the sick agent remains sick. If this occurs and these remaining agents have care-giving skills that the sick agent needs, they can provide care.
The remaining carers give care based on a modified version of Hamilton’s Rule55. Hamilton’s rule states that individuals should behave altruistically when: (benefit to the recipient) * (relatedness with the recipient) >(cost). We expressed the costs and benefits in terms of disease risk, such that:
The benefits are based on medical literature (Table 1) documenting reductions in disease parameters (i.e., transmission, fatality). Benefits are calculated as the sum of the change in the agent’s disease parameters (probabilities of transmission, fatality, and recovery). In Hamilton’s rule, we divided the transmission rate by the number of carers (up to four, one for each care type) to reflect that carers providing cooperative care will be able to reduce the time spent in close proximity to the diseased individual, thus enabling each individual carer to minimize their exposure. Each type of care improves one of the agent’s personal disease parameters: probability of death, probability of transmission, probability of recovery. The new disease parameter is used to solve the exponential equation of pathogen replication for a reduced pathogen load and corresponding reductions in the other disease parameters. This also provides indirect benefits to future carers by lowering the probability of transmission. All carers, except for pair-partners and altruists, cease providing care when the costs exceed the benefits, according to a modified version of Hamilton’s rule55 in which the costs and benefits are expressed in terms of disease risk (infectiousness of the infected individual, death rate of the disease, and recovery rate).
After providing care, carers receive a random number. If it is below the probability of transmission/number of care types the agent received, then the carer is infected. If the carer is not infected, it attempts to learn new care-giving skills. Carers can learn skills from carers with whom they provided cooperative care. The carer goes through the list of types of care that the diseased agent received and draws a random number for each. If it is below the carer’s intelligence, then the carer adds that skill to its repertoire.
Diseased agents then receive a random number, if it is below their personal probability of death, then they die. If it is above, they survive to attempt recovery. They receive a random number and if it is below (1 − personal probability of recovery), then the agent recovers. If not, the agent remains diseased. Agents within 10 grid cells of a diseased agent select a random number. If it is below that diseased agent’s probability of transmission, the agent is infected. Healthy agents move to an unoccupied grid cell within a radius of 10 grid cells. Both the infection radius and movement radius are set to the same value (20 km2). This is the maximum distance which hunter-gatherers typically forage in a day49,53, thus it represents individuals close enough to interact with the diseased agent when it is infectious.
We reduced each of the social systems to its care-giving networks (Table S1). These networks are not synonymous with the mating system. We describe the care-giving networks and mating networks in each social system:
In most animal species, including primates6, the only extensive care-giving that occurs is from the mother to the offspring. This bond is given a relatedness value of 0.5, representing matrilineal relatedness. No cooperative care occurs, thus diseased individuals receive a maximum of one type of care. Females reproduce without forming bonds with males.
Pair-bonding has been argued to be the underlying structure of the human social systems, enabling both matrilineal and patrilineal kin recognition and facilitating cooperation across kin communities (via in-laws)42. While this may have been important for reducing violence and competition between communities42, pair-bonding and bisexual dispersal are associated with lower levels of kinship within communities43,74. Thus, in our model, the care-giving bonds are the basal mother-offspring bond, the father-offspring bond, and the pair-bond between the mother and father. Parent-offspring bonds receive relatedness values of 0.5, reflecting the genetic relationship. No grandparent or sibling care is given. Pair-partners provide obligate care to each other (if they recognize the disease and have the necessary care-giving skills), reflecting mating effort and/or reproductive investment in the mate. Unpaired males and unpaired females are randomly paired. To eliminate confounding effects of assortative mating by intelligence, pair-bonded males are assigned the intelligence scores of the female partner. This creates a simplified two parent system without introducing selection for an intelligent mate. Only pair-bonded females reproduce.
This social system reflects the literature in which meat sharing by hunting males in a community serves to bridge periods of ill health44,45. Males share food with individuals who are sick and unable to provide for themselves, and in the future when they, themselves, are ill, they receive food from community members. This reciprocity is indirect because the future givers may not be the same individuals who receive in the present44,45. We parameterize this social system to be the same as the pair-bonded system, except that diseased individuals receive food provisions from randomly selected male altruists. Food is provided regardless of the risks and regardless of disease recognition. As in the pair-bonded system, unpaired males and unpaired females are randomly paired. Only pair-bonded females reproduce.
This social system includes the basal mother-offspring care and care from matrilineal relatives with relatedness values of 0.125 or greater. This is consistent with the levels of kin recognition observed in nonhuman animals (Table 1). This includes sibling care47, grandparent care14, and care from other matrilineal relatives. It reflects the ethnographic literature on the BaYaka detailing how knowledge of medicinal plants is shared within, but not widely beyond, kin networks59. Care is bi-directional reflecting that care-giving occurs across generations, including contributions by immatures who would be capable of provisioning ill individuals with water, providing hygiene assistance, or providing some protection by staying with an ill individual. Although this social system is conceptualized with females remaining in their natal communities, the findings are not specific to matrilineal kin networks. In societies where females disperse74, patrilineal kin could provide care. Such kin-based care is not dependent upon continued investment by the father and would also be successful in promiscuous or polygynous societies74. As in the basal system, females reproduce without forming bonds with males.
The Ineffective Care Model simulates the difficulties of establishing care-giving in a community that provides ineffective care while undergoing repeated introductions of novel diseases. Each time an agent provided care, the value of the benefits of the care was a random number between 0 and the maximum value found in the literature (Table 1). Because the disease parameters determine how the disease progresses through the community, novel diseases were created by assigning disease parameters random numbers between 0 and 0.5. We focused this disease range because, based on prior work1, that is where we expected the most care-giving to occur in all social systems.
The Effective Care Model examines the effects of social system and disease parameters once effective care-giving has been established in the population. Under this model, the benefits of care were fixed at the values found in the literature (Table 1). Disease parameters were varied simultaneously between 0.1 and 0.9. For example a disease with a severity of 0.1 had a death rate of 0.1, transmission rate of 0.1, and recovery rate of 0.9.
Each model was run under each of the four social systems. Carrying capacity was run with settings of 50, 100, 150, and 200 individuals. The initial prevalence of the disease was run at settings of 5%, 25%, 50%, and 75%. Each parameter combination, for each social system, for each model, was run 100 times. Runs were 1000 time steps. Runs were stopped and discarded if the population could no longer reproduce (i.e., there were less than two individuals of each sex or there were no healthy agents left).
At the end of each run, the model output: mean number of care events received by diseased agents per infection (cooperative care), mean percentage of diseased agents to receive at least one type of care (percent care), mean number of care-giving skills per agent (skills), the net intelligence change between the start of the first time step and the end of the last (intelligence change), mean number of time steps required for a disease to go extinct (disease extinction), and mean percentage of agents infected by other agents (disease spread). Each of these parameters (except for intelligence change) was calculated separately for each disease event, then averaged across disease events to produce an average value for that run. We used a model fitting, not hypothesis testing, approach to examine how the output variables varied between social systems, and what predictor variables (i.e., community size, initial prevalence, disease severity) explained the variation between runs in each social system. We ran linear mixed models in R75 using lme476 including all possible combinations of interactions. For each model, we grouped the data by social system and allowed the main effects to vary by social system, i.e., a random intercept and slope model design was used. Thus, for both models, social system was a random variable and the predictor variables and interaction effects were fixed (Ineffective Care Model’s fixed variables: Community Size, Initial Prevalence, Community Size * Initial Prevalence; Effective Care Model’s fixed variables: Community Size, Initial Prevalence, Disease Severity, and all corresponding interactions). We estimate both the marginal and conditional R2 for each model77. The marginal R2 estimates the ability of the model’s fixed effects to explain variation, whereas the conditional R2 takes into account both the fixed and random components, i.e., random intercept and slopes for each social system. The difference between the two measures provides an estimate of how much variation can be explained by the differences between social systems. We calculated AIC scores and present the results of the models which best fit the data (Table 2). Comparisons among all possible models are presented in Table S2.
We confirm that all methods were carried out in accordance with relevant guidelines and regulations. Because this study used no live subjects it did not require informed consent or institutional licensing.
Data Availability Statement
Code for the Ineffective Care and Effective Care Models has been provided in the Supplementary Materials. The.nlogo files can be opened with a text editor or run in Netlogo using the BehaviorSpace tool. The Supplementary Materials also contain ODD (Overview, Design Concepts, Details) protocols describing how to use the models. Code for the linear mixed models is available upon request. The datasets, including a list of the random seeds used in the runs, are available upon request. By uploading the random seed data into the models, users can reproduce the exact runs that output the datasets in this paper.
Kessler, S. E., Bonnell, T. R., Byrne, R. W. & Chapman, C. Selection to outsmart the germs: The evolution of disease recognition and kin selection. J. Hum. Evol. 108, 92 (2017).
Whiten, A. et al. Studying extant species to model our past. Science 327(5964), 410 (2010).
De Waal, F. B. M. The antiquity of empathy. Science 336(6083), 874 (2012).
Antón, S. C., Potts, R. & Aiello, L. C. Evolution of early homo: An integrated biological perspective. Science 345, 6192 (2014).
Shultz, S., Nelson, E. & Dunbar, R. I. M. Hominin cognitive evolution: Identifying patterns and processes in the fossil and archaeological record. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 367(1599), 2130 (2012).
Burkart, J. et al. The evolutionary origin of human hyper-cooperation. Nature Communications 5, 4747 (2014).
Herrmann, E., Call, J., Hernández-Lloreda, M. V., Hare, B. & Tomasello, M. Humans have evolved specialized skills of social cognition: The cultural intelligence hypothesis. Science 317, 1360 (2007).
Dunbar, R. & Shultz, S. Evolution in the social brain. Science 317(5843), 1344 (2007).
Dean, L. G., Kendal, R. L., Schapiro, S. J., Thierry, B. & Laland, K. N. Identification of the social and cognitive processes underlying human cummulative culture. Science 335, 1114 (2012).
Desilva, J. M. A shift toward birthing relatively large infants early in human evolution. Proc. Natl. Acad. Sci. USA 108(3), 1022 (2011).
Aiello, L. C. & Key, C. Energetic consequences of being a homo erectus female. Am. J. Hum. Biol. 14, 551 (2002).
Hrdy, S. B. Mothers and others: The evolutionary origins of mutual understanding. (Belknap Press of Harvard University Press, Cambridge, 2009).
Burkart, J. M., Hrdy, S. B. & Van Schaik, C. P. Cooperative breeding and human cognitive evolution. Evol. Anthropol. 18(5), 175 (2009).
Hawkes, K., O’connell, J., Blurton Jones, N., Alvarez, H. & Charnov, E. Grandmothering, menopause, and the evolution of human life histories. Proceedings of the National Academy of Sciences 95, 1336 (1998).
Clay, Z. & De Waal, F. B. M. Development of socio-emotional competence in bonobos. Proceedings of the National Academy of Sciences 110(45), 18121 (2013).
Regenbogen, C. et al. Behavioral and neural correlates to multisensory detection of sick humans. Proc. Natl. Acad. Sci. USA 114(24), 6400 (2017).
Dunbar, R. The social brain hypothesis. Evol. Anthropol. 6(5), 178 (1998).
Tomasello, M. The ultra-social animal. European Journal of Social Psychology 44, 187 (2014).
Boyd, R. & Richerson, P. J. Culture and the evolution of human cooperation. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 364(1533), 3281 (2009).
Hill, K., Barton, M. & Hurtado, A. The emergence of human uniqueness: Characters underlying behavioral modernity. Evol. Anthropol. 18, 187 (2009).
Ezenwa, V. O., Ghai, R. R., Mckay, A. F. & Williams, A. E. Group living and pathogen infection revisited. Current Opinion in Behavioral Sciences 12(Supplement C), 66 (2016).
Nunn, C. L., Jordán, F., Mccabe, C. M., Verdolin, J. L. & Fewell, J. H. Infectious disease and group size: More than just a numbers game. Philosophical Transactions of the Royal Society B: Biological Sciences 370, 1669 (2015).
Meunier, J. Social immunity and the evolution of group living in insects. Philosophical Transactions of the Royal Society B: Biological Sciences 370(1669), 20140102 (2015).
Harper, K. N. & Armelagos, G. J. Genomics, the origins of agriculture, and our changing microbe-scape: Time to revisit some old tales and tell some new ones. Am. J. Phys. Anthropol. 152, 135 (2013).
Stone, A. C., Wilbur, A. K., Buikstra, J. E. & Roberts, C. A. Tuberculosis and leprosy in perspective. Yearb. Phys. Anthropol. 52, 66 (2009).
Jones, K. E. et al. Global trends in emerging infectious diseases. Nature 451(7181), 990 (2008).
Simonti, C. N. et al. The phenotypic legacy of admixture between modern humans and neandertals. Science 351(6274), 737 (2016).
Vernot, B. et al. Excavating neandertal and denisovan DNA from the genomes of melanesian individuals. Science 352(6282), 235 (2016).
Quach, H. et al. Genetic adaptation and neandertal admixture shaped the immune system of human populations. Cell 167(3), 643 (2016).
Gokhman, D. et al. Reconstructing the DNA methylation maps of the neandertal and the denisovan. Science 344(6183), 523 (2014).
Vernot, B. & Akey, J. M. Resurrecting surviving neandertal lineages from modern human genomes. Science 343(6174), 1017 (2014).
Sankararaman, S. et al. The landscape of neandertal ancestry in present-day humans. Nature 507(7492), 354 (2014).
Kuhlwilm, M. et al. Ancient gene flow from early modern humans into eastern neanderthals. Nature 530(7591), 429 (2016).
Shakhar, K. & Shakhar, G. Why do we feel sick when infected-can altruism play a role? PLoS Biol. 13(10), 15 (2015).
Hennessy, M. B., Deak, T. & Schiml, P. A. Sociality and sickness: Have cytokines evolved to serve social functions beyond times of pathogen exposure? Brain Behav. Immun. 37, 15 (2014).
Hublin, J. J. The prehistory of compassion. Proceedings of the National Academy of Sciences 106, 6429 (2009).
Lebel, S. et al. Comparative morphology and paleobiology of middle pleistocene human remains from the bau de l’aubesier, vaucluse, france. Proceedings of the National Academy of Sciences 98, 11097 (2001).
Lordkipanidze, D. et al. The earliest toothless hominin skull. Nature 434(7034), 717 (2005).
Degusta, D. Aubesier 11 is not evidence of neanderthal conspecific care. J. Hum. Evol. 45(1), 91 (2003).
Beamish, E. K. & O’riain, M. J. The effects of permanent injury on the behavior and diet of commensal chacma baboons (papio ursinus) in the cape peninsula, south africa. Int. J. Primatol. 35(5), 1004 (2014).
Silk, J. B. Social components of fitness in primate groups. Science 317(5843), 1347 (2007).
Chapais, B. The deep social structure of humankind. Science 331(6022), 1276 (2011).
Dyble, M. et al. Sex equality can explain the unique social structure of hunter-gatherer bands. Science 348(6236), 796 (2015).
Gurven, M., Allen-Arave, W., Hill, K. & Hurtado, M. “It’s a wonderful life”: Signaling generosity among the ache of paraguay. Evolution and Human Behavior 21(4), 263 (2000).
Sugiyama, L. S. Illness, injury, and disability among shiwiar forager-horticulturists: Implications of health-risk buffering for the evolution of human life history. Am. J. Phys. Anthropol. 123(4), 371 (2004).
Hill, K. & Hurtado, A. Cooperative breeding in south american hunter-gatherers. Proceedings of the Royal Society B 276, 3863 (2009).
Sear, R. & Mace, R. Who keeps children alive? A review of the effects of kin on child survival. Evolution and Human Behavior 29(1), 1 (2008).
Hill, K. & Hurtado, A. M. Human reproductive assistance. Nature 483(7388), 160 (2012).
Grove, M., Pearce, E. & Dunbar, R. I. M. Fission-fusion and the evolution of hominin social systems. J. Hum. Evol. 62(2), 191 (2012).
Gamble, C., Gowlett, J. & Dunbar, R. The social brain and the shape of the palaeolithic. Cambridge Archaeological Journal 21(1), 115 (2011).
Lwanga, J. S., Struhsaker, T. T., Struhsaker, P. J., Butynski, T. M. & Mitani, J. C. Primate population dynamics over 32.9 years at ngogo, kibale national park, uganda. Am. J. Primatol. 73, 997 (2011).
Wood, B. M., Watts, D. P., Mitani, J. C. & Langergraber, K. E. Favorable ecological circumstances promote life expectancy in chimpanzees similar to that of human hunter-gatherers. J. Hum. Evol. 105, 41 (2017).
Layton, R., O’hara, S. & Bilsborough, A. Antiquity and social functions of multilevel social organization among human hunter-gatherers. Int. J. Primatol. 33(5), 1215 (2012).
Reader, S. M., Hager, Y. & Laland, K. N. The evolution of primate general and cultural intelligence. Philosophical Transactions of the Royal Society B: Biological Sciences 366(1567), 1017 (2011).
Hamilton, W. D. The genetical evolution of social behavior. I and ii. J. Theor. Biol. 7, 1 (1964).
Haas, C. Conditional dose-response relationships for microorganisms: Development and application. Risk Anal. 22(3), 455 (2002).
Rose, J., Haas, C., Gurian, P., Mitchell, J., and Weir, M., (The Center for Advanced Microbial Risk Assessment at Michigan State University, 2014).
Hill, K. R., Wood, B. M., Baggio, J., Hurtado, A. M. & Boyd, R. T. Hunter-gatherer inter-band interaction rates: Implications for cumulative culture. Plos One 9(7), 9 (2014).
Salali, G. D. et al. Knowledge-sharing networks in hunter-gatherers and the evolution of cumulative culture. Curr. Biol. 26(18), 2516 (2016).
Alizon, S. & Michalakis, Y. Adaptive virulence evolution: The good old fitness-based approach. Trends Ecol. Evol. 30(5), 248 (2015).
Who-recommended surveillance standard of pertussis, (2017). World Health Organization. Accessed October 31, 2017.
Typhoid fever, (2013). Centers for Disease Control and Prevention. Accessed May 2, 2016.
Tuberculosis, (2017). World Health Organization. Accessed October 31, 2017.
Piantadosi, S. T. & Kidd, C. Extraordinary intelligence and the care of infants. Proc. Natl. Acad. Sci. USA 113(25), 6874 (2016).
David-Barrett, T. & Dunbar, R. I. M. Bipedality and hair loss in human evolution revisited: The impact of altitude and activity scheduling. J. Hum. Evol. 94, 72 (2016).
Provine, R. R., Cabrera, M. O., Brocato, N. W. & Krosnowski, K. A. When the whites of the eyes are red: A uniquely human cue. Ethology 117(5), 395 (2011).
Nguyen, D. H., Hurtado-Ziola, N., Gagneux, P. & Varki, A. Loss of siglec expression on t lymphocytes during human evolution. Proc. Natl. Acad. Sci. USA 103(20), 7765 (2006).
Varki, A. Are humans prone to autoimmunity? Implications from evolutionary changes in hominin sialic acid biology. J. Autoimmun. 83, 134 (2017).
Webster, J. P., Borlase, A. & Rudge, J. W. Who acquires infection from whom and how? Disentangling multi-host and multi-mode transmission dynamics in the ‘elimination’ era. Philosophical Transactions of the Royal Society B: Biological Sciences 372, 1719 (2016).
Keeling, M.J. and Rohani, P., Modeling infectious diseases in humans and animals. (Princeton University Press, Princeton, 2008).
Keeling, M. J. & Grenfell, B. T. Disease extinction and community size: Modeling the persistence of measles. Science 275(5296), 65 (1997).
Blake, A. et al. Temporo-spatial dynamics and behavioural patterns of 2012 cholera epidemic in the african mega-city of conakry, guinea. Infectious Diseases of Poverty 7, 10 (2018).
Griffin, R. & Nunn, C. Community structure and the spread of infectious disease in primate social networks. Evol. Ecol. 26, 779 (2012).
Hill, K. R. et al. Co-residence patterns in hunter-gatherer societies show unique human social structure. Science 331(6022), 1286 (2011).
Rcoreteam, R: A language and environment for statistical computing (R Foundation for Statistical Computing, Vienna, Austria, 2017).
Bates, D., Maechler, M., Bolker, B. & Walker, S. Fitting linear mixed-effects models using lme4. Journal of Statistical Software 67(1), 1 (2015).
Nakagawa, S. & Schielzeth, H. A general and simple method for obtaining r2 from generalized linear mixed-effects models. Methods in Ecology and Evolution 4(2), 133 (2013).
Plomin, R. Genetics and general cognitive ability. Nature 402(6761), C25 (1999).
Chapais, B. & Berman, C. M. eds, Kinship and behavior in primates. (Oxford University Press, New York, 2004).
Ashworth, A. et al. Who guidelines for management of severe malnutrition in rural south african hospitals: Effect on case fatality and the influence of operational factors. The Lancet 363(9415), 1110 (2004).
Bryce, J., Boschi-Pinto, C., Shibuya, K. & Black, R. E. Who estimates of the causes of death in children. The Lancet 365(9465), 1147 (2005).
Caulfield, L., De Onis, M., Bloessner, M. & Black, R. E. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am. J. Clin. Nutr. 80, 193 (2004).
Diallo, A. F., Cong, X., Henderson, W. A. & Mcgrath, J. Management of childhood diarrhea by healthcare professionals in low income countries: An integrative review. Int. J. Nurs. Stud. 66, 82 (2017).
Liu, L. et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: An updated systematic analysis. The Lancet 385(9966), 430 (2015).
Esrey, S. A., Potash, J. B., Roberts, L. & Shiff, C. Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. Bull. World Health Organ. 69(5), 609 (1991).
Curtis, V. & Cairncross, S. Effect of washing hands with soap on diarrhoea risk in the community: A systematic review. The Lancet Infectious Diseases 3(5), 275 (2003).
Aiello, A. E. & Larson, E. L. What is the evidence for a causal link between hygiene and infections? The Lancet Infectious Diseases 2(2), 103 (2002).
This work was funded by a Marie Sklodowska-Curie Individual Fellowship (#703611) to SEK and mentored by JMS.
The authors declare no competing interests.
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Kessler, S.E., Bonnell, T.R., Setchell, J.M. et al. Social Structure Facilitated the Evolution of Care-giving as a Strategy for Disease Control in the Human Lineage. Sci Rep 8, 13997 (2018). https://doi.org/10.1038/s41598-018-31568-2
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