Dystrophin-associated complex (DAC) gene expression is associated with dementia status and temporal cortical P-tau levels. (A) Schematic of the DAC at the astrocytic endfoot membrane. Known components of the complex include aquaporin-4 (AQP4), α-syntrophin (SNTA1), dystrobrevin (DTNA), dystrophin (DMD) and dystroglycan (DAG1). (B–E) Expression levels of the 4 DAC components across the 4 brain regions. DTNA and DAG1 demonstrate significantly elevated expression in the HIP of subjects with dementia (t = 2.731, 2.632; padj = 0.009, 0.013; respectively), while DMD expression is reduced in HIP among subjects with dementia (t = −2.615, padj = 0.013). (F–I) Association of DAC gene expression with TCX P-tau levels. SNTA and DAG1 demonstrate associations with tau pathology regardless of dementia status (t = 2.380, 3.29; padj = 0.038, 0.010; respectively). The bars in figures (B–E) represent the mean ± the standard deviation (S.D.). The line in figures (F,H) represent the least squares (ordinary) fit for all data. All statistical associations between gene expression and dementia status assessed using logistic regression. All statistical associations between gene expression and pathology indicators were evaluated using OLS regression.